The P268S and M863V Polymorphisms of the NOD2/CARD15 Gene in Crohn's Disease and Ulcerative Colitis

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dc.contributor.authorDiler, Songul Budak
dc.contributor.authorPolat, Fikriye
dc.contributor.authorYaras, Serkan
dc.date.accessioned2024-11-07T13:32:59Z
dc.date.available2024-11-07T13:32:59Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractWe aimed to determine P268S and M863V polymorphisms in NOD2/CARD15 genes associated with an increased risk of developing Crohn's disease (CD) and ulcerative colitis (UC) and to establish correlations between P268S and M863V genotypes in Turkish population. This study included 152 healthy controls and 138 patients (62 CD and 76 UC) with IBD. Our results, the P268S CC genotype was prevalent on patients and controls (45 vs. 66%), followed by genotypes CT (48 vs. 28%) and TT (7 vs. 6%) in CD. The prevalence of genotypes of CC (wild-type), CT (heterozygous mutant) and TT (homozygous mutant) profiles for the P268S polymorphism were 68, 25 and 7% respectively in UC patients, and 66, 28 and 6% respectively in healthy control groups. We were found in wild-type M863V in all subjects and no other mutant band. P268S polymorphism may be associated with CD susceptibility in Turkish population, whereas there is not associated between M863V polymorphisms and patients with IBD in Turkish population.
dc.description.sponsorshipScientific Research Project Unit of Nigde Omer Halisdemir University; FEB [2015/19 BAGEP]
dc.description.sponsorshipWe would like to thank the Scientific Research Project Unit of Nigde Omer Halisdemir University (project no. FEB 2015/19 BAGEP).
dc.identifier.doi10.3103/S0095452719050074
dc.identifier.endpage429
dc.identifier.issn0095-4527
dc.identifier.issn1934-9440
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85073245618
dc.identifier.scopusqualityQ4
dc.identifier.startpage424
dc.identifier.urihttps://doi.org/10.3103/S0095452719050074
dc.identifier.urihttps://hdl.handle.net/11480/15729
dc.identifier.volume53
dc.identifier.wosWOS:000488928400010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAllerton Press Inc
dc.relation.ispartofCytology and Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectulcerative colitis
dc.subjectCrohn's disease
dc.subjectNOD2
dc.subjectCARD15 gene
dc.subjectsingle nucleotide polymorphism
dc.subjectRFLP
dc.titleThe P268S and M863V Polymorphisms of the NOD2/CARD15 Gene in Crohn's Disease and Ulcerative Colitis
dc.typeArticle

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