Identifying Clinical Characteristics of Hypoparathyroidism in Turkey: HIPOPARATURK-NET Study

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dc.authoridKonca Degertekin, Ceyla/0000-0003-0299-6596
dc.authoridyilmaz, merve/0000-0002-3421-8548
dc.authoridSAYGILI, Emre Sedar/0000-0003-0022-5704
dc.authoridGogas Yavuz, Dilek/0000-0002-0075-6313
dc.contributor.authorDegertekin, Ceyla Konca
dc.contributor.authorYavuz, Dilek Gogas
dc.contributor.authorPekkolay, Zafer
dc.contributor.authorSaygili, Emre
dc.contributor.authorUgur, Kader
dc.contributor.authorKoca, Arzu Or
dc.contributor.authorUnubol, Mustafa
dc.date.accessioned2024-11-07T13:35:36Z
dc.date.available2024-11-07T13:35:36Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractHypoparathyroidism is an orphan disease with ill-defined epidemiology that is subject to geographic variability. We conducted this study to assess the demographics, etiologic distribution, treatment patterns and complication frequency of patients with chronic hypoparathyroidism in Turkey. This is a retrospective, cross-sectional database study, with collaboration of 30 endocrinology centers located in 20 cities across seven geographical regions of Turkey. A total of 830 adults (mean age 49.6 +/- 13.5 years; female 81.2%) with hypoparathyroidism (mean duration 9.7 +/- 9.0 years) were included in the final analysis. Hypoparathyroidism was predominantly surgery-induced (n = 686, 82.6%). The insulting surgeries was carried out mostly due to benign causes in postsurgical group (SG) (n = 504, 73.5%) while patients in nonsurgical group (NSG) was most frequently classified as idiopathic (n = 103, 71.5%). The treatment was highly dependent on calcium salts (n = 771, 92.9%), calcitriol (n = 786, 94.7%) and to a lower extent cholecalciferol use (n = 635, 76.5%) while the rate of parathyroid hormone (n = 2, 0.2%) use was low. Serum calcium levels were most frequently kept in the normal range (sCa 8.5-10.5 mg/dL, n = 383, 46.1%) which might be higher than desired for this patient group. NSG had a lower mean plasma PTH concentration (6.42 +/- 5.53 vs. 9.09 +/- 7.08 ng/l, p < 0.0001), higher daily intake of elementary calcium (2038 +/- 1214 vs. 1846 +/- 1355 mg/day, p = 0.0193) and calcitriol (0.78 +/- 0.39 vs. 0.69 +/- 0.38 mcg/day, p = 0.0057), a higher rate of chronic renal disease (9.7% vs. 3.6%, p = 0.0017), epilepsy (6.3% vs. 1.6%, p = 0.0009), intracranial calcifications (11.8% vs. 7.3%, p < 0.0001) and cataracts (22.2% vs. 13.7%, p = 0.0096) compared to SG. In conclusion, postsurgical hypoparathyroidism is the dominant etiology of hypoparathyroidism in Turkey while the nonsurgical patients have a higher disease burden with greater need for medications and increased risk of complications than the postsurgical patients.
dc.identifier.doi10.1007/s00223-021-00908-2
dc.identifier.endpage214
dc.identifier.issn0171-967X
dc.identifier.issn1432-0827
dc.identifier.issue2
dc.identifier.pmid34495356
dc.identifier.scopus2-s2.0-85114447165
dc.identifier.scopusqualityQ1
dc.identifier.startpage204
dc.identifier.urihttps://doi.org/10.1007/s00223-021-00908-2
dc.identifier.urihttps://hdl.handle.net/11480/16579
dc.identifier.volume110
dc.identifier.wosWOS:000695738900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofCalcified Tissue International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectHypoparathyroidism
dc.subjectHypocalcemia
dc.subjectEpidemiology
dc.subjectTurkey
dc.subjectParathyroid hormone
dc.titleIdentifying Clinical Characteristics of Hypoparathyroidism in Turkey: HIPOPARATURK-NET Study
dc.typeArticle

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