Ginkgetin: A natural biflavone with versatile pharmacological activities

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dc.authoridZahoor, Muhammad Kashif/0000-0003-0309-9758
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authoridRiaz, Ammara/0000-0001-5025-9182
dc.authoridShah, Muhammad Ajmal/0000-0003-3471-184X
dc.contributor.authorAdnan, Muhammad
dc.contributor.authorRasul, Azhar
dc.contributor.authorHussain, Ghulam
dc.contributor.authorShah, Muhammad Ajmal
dc.contributor.authorZahoor, Muhammad Kashif
dc.contributor.authorAnwar, Haseeb
dc.contributor.authorSarfraz, Iqra
dc.date.accessioned2024-11-07T13:34:05Z
dc.date.available2024-11-07T13:34:05Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractNatural products, being richly endowed with curative powers, have become spotlight for biomedical and pharmaceutical research to develop novel therapeutics during recent years. Ginkgetin (GK), a natural non-toxic biflavone, has been shown to exhibit anti-cancer, anti-inflammatory, anti-microbial, anti-adipogenic, and neuroprotective activities. GK combats cancer progression by arresting cell cycle, inducing apoptosis, stimulating autophagy, and targeting many deregulated signaling pathways such as JAK/STAT and MAPKs. GKhalts inflammation mediators like interleukins, iNOS, COX-2, PGE2, NF-0, and acts as an inhibitor of PLA2. GK shows strong neuroprotection against oxidative stress-promoted cell death, inhibits cerebral micro -hemorrhage, decreases neurologic deficits, and halts apoptosis of neurons. GK also acts as anti-fungal, anti-viral, anti-bacterial, leishmanicidal and anti-plasmodial agent. GK shows substantial preventive or therapeutic effects in in vivo models of many diseases including atherosclerosis, cancer, neumdegenerative, hepatic, influenza, and inflammatory diseases. Based on various computational, in vitro and in vivo evidences, this article demonstrates the potential of ginkgetin for development of therapeutics against various diseases. Although GK has been systematically studied from pharmacological point of view, a vast field of pharmacokinetics, pre-clinical and clinical studies is still open for the researchers to fully validate its potential for the treatment of various diseases.
dc.description.sponsorshipNagai Foundation Tokyo, Japan [NFT-R-2018]; NRPU Research Grants [8381/Punjab/NRPU/RD/HEC/2017, 8382/Punjab/NRPU/RD/HEC/2017]
dc.description.sponsorshipThis study is done under the support of The Nagai Foundation Tokyo, Japan (NFT-R-2018) and NRPU Research Grants (8381/Punjab/NRPU/R&D/HEC/2017, 8382/Punjab/NRPU/R&D/HEC/2017).
dc.identifier.doi10.1016/j.fct.2020.111642
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.pmid32783998
dc.identifier.scopus2-s2.0-85089500069
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.fct.2020.111642
dc.identifier.urihttps://hdl.handle.net/11480/15786
dc.identifier.volume145
dc.identifier.wosWOS:000580355300012
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectGinkgetin
dc.subjectBiflavone
dc.subjectAnti-cancer
dc.subjectAnti-inflammatory
dc.subjectAnti-microbial
dc.subjectNeuroprotective
dc.titleGinkgetin: A natural biflavone with versatile pharmacological activities
dc.typeArticle

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