Investigation of the effects of bisphenol-A exposure on lymphoid system in prenatal stage

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dc.authoridAYDEMIR, ISIL/0000-0002-4143-7319
dc.authoridKUM, Sadiye/0000-0001-6586-4596
dc.authoridOZBEY, CANER/0000-0002-5001-5150
dc.contributor.authorAydemir, Isil
dc.contributor.authorOzbey, Caner
dc.contributor.authorOzkan, Oktay
dc.contributor.authorTuglu, Mehmet Ibrahim
dc.contributor.authorKum, Sadiye
dc.date.accessioned2024-11-07T13:34:09Z
dc.date.available2024-11-07T13:34:09Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBisphenol-A (BPA) used in the production of plastic materials is a temperature-soluble agent. It also has a steroid hormone-like activity; therefore, it poses a danger to human health. In our study, we aimed to investigate the effects of BPA on lymph node and spleen in male rats exposed to this agent during prenatal stage. The pregnant female rats were divided into four groups: control, sham, low dose (300 mu g/kg BPA), and high dose (900 mu g/kg BPA). BPA was dissolved in 1 mL of corn oil and administered to the pregnant rats every day during pregnancy. On the 21st and 45th day after the birth, male rats' lymph node and spleen samples were taken and histopathological examination was performed. Samples were stained with hematoxylin and eosin to determine the general histological appearance, and with CD3 and CD20 immunohistochemically. The results of staining were evaluated by H-score, and statistical analysis was performed. In the samples, BPA applications were not found to cause significant tissue damage. But there was a significant decrease in the immunoreactivities of CD3 and CD20 after BPA applications in both 21st and 45th day samples. After high dose BPA administration, decreased CD3 immunoreactivity was statistically significant. It is thought that BPA does not cause histologically significant tissue damage, but it may impair organ function at cellular level. The investigation of molecules involved in organ function will be useful in revealing the mechanisms that will cause dysfunction.
dc.identifier.doi10.1177/0748233720941759
dc.identifier.endpage513
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue7
dc.identifier.pmid32696725
dc.identifier.scopus2-s2.0-85088367909
dc.identifier.scopusqualityQ3
dc.identifier.startpage502
dc.identifier.urihttps://doi.org/10.1177/0748233720941759
dc.identifier.urihttps://hdl.handle.net/11480/15829
dc.identifier.volume36
dc.identifier.wosWOS:000551980400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectBisphenol-A
dc.subjectlymph node
dc.subjectspleen
dc.subjectCD3
dc.subjectCD20
dc.subjecthistology
dc.titleInvestigation of the effects of bisphenol-A exposure on lymphoid system in prenatal stage
dc.typeArticle

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