A new definition about the relationship of intercellular fluid in the brain with the mandibular and parotid lymph nodes

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dc.authoridErdogan, Ender/0000-0002-6220-9243
dc.authoridSOLMAZ, MERVE/0000-0003-4144-4647
dc.authoridPerez, William/0000-0002-9647-4731
dc.authoridUNLUKAL, NEJAT/0000-0002-8107-4882
dc.contributor.authorNur, Ismail Hakki
dc.contributor.authorKeles, Haci
dc.contributor.authorUnlukal, Nejat
dc.contributor.authorSolmaz, Merve
dc.contributor.authorErdogan, Ender
dc.contributor.authorPerez, William
dc.date.accessioned2024-11-07T13:34:42Z
dc.date.available2024-11-07T13:34:42Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThis study was carried out to reveal the relationship of the brain with both the mandibular lymph node (MLN) and parotid lymph node (PLN) by the hyperspectral fluorescence imaging techniques of Qdot 800 (QD) nanoparticles using in vivo. This relationship of the brain with both lymph nodes offers the preliminary morphological definition of lymphatic drainage. QD was injected into the left parietal brain lobe of each rat at a depth of 2.50 mm. In 65% of the rats that were imaged in vivo, signals were received first from the right MLN and PLN, and then from the left MLN and PLN. In contrast, in two female rats, the first signal was received from the right PLN. There was no difference between the female and male rats overall. The most noteworthy finding of this study was that the tracer injected into the left parietal lobe reached the right mandibular and parotid lymph nodules earlier. This result indicates a different and unknown pathway in the brain that communicates with the lymph nodes. Moreover, this study shows that these lymph nodes pathways can be used in the treatment of diseases such as brain trauma, cerebral edema, and Alzheimer's disease (AD).
dc.description.sponsorshipUnit of Scientific Research Projects of Erciyes Universitesi [TOA-2018-8500]
dc.description.sponsorshipThe authors gratefully acknowledge Associate Professor Catrin Rutland, University of Nottingham (UK), for her assistance with the English language editing of this manuscript. The authors are grateful for the financial support provided by the Unit of Scientific Research Projects of Erciyes Universitesi (Project no: TOA-2018-8500).
dc.identifier.doi10.1002/jemt.23898
dc.identifier.endpage232
dc.identifier.issn1059-910X
dc.identifier.issn1097-0029
dc.identifier.issue1
dc.identifier.pmid34369631
dc.identifier.scopus2-s2.0-85112657964
dc.identifier.scopusqualityQ1
dc.identifier.startpage220
dc.identifier.urihttps://doi.org/10.1002/jemt.23898
dc.identifier.urihttps://hdl.handle.net/11480/16130
dc.identifier.volume85
dc.identifier.wosWOS:000682967300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofMicroscopy Research and Technique
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectbrain drainage
dc.subjectglymphatic system
dc.subjectintracellular fluid
dc.subjectlymph nodes
dc.subjectQdot 800
dc.titleA new definition about the relationship of intercellular fluid in the brain with the mandibular and parotid lymph nodes
dc.typeArticle

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