FOXP3 rs3761548 polymorphism is associated with knee osteoarthritis in a Turkish population

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dc.authoridBildirici, Aslihan Esra/0000-0003-2438-3723
dc.authoridArslan, Serdal/0000-0002-3921-8061
dc.contributor.authorCekin, Nilgun
dc.contributor.authorPinarbasi, Ergun
dc.contributor.authorBildirici, Aslihan Esra
dc.contributor.authorDonmez, Gonca
dc.contributor.authorOztemur, Zekeriya
dc.contributor.authorBulut, Okay
dc.contributor.authorArslan, Serdal
dc.date.accessioned2024-11-07T13:32:17Z
dc.date.available2024-11-07T13:32:17Z
dc.date.issued2018
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAim: Functional polymorphisms located in FOXP3 intron 1 was recently found to be associated with rheumatoid arthritis (RA). Although RA is an autoimmune disease, there is supporting evidence that activated maladaptive responses including pro-inflammatory pathways play roles in osteoarthritis (OA), similar to RA. The aim of this study was to explore the relationship between rs2232365 (-924A/G) and rs3761548 (-3279A/C) polymorphisms as well as possible changes in the 600 bp promoter region of FOXP3 and knee OA. Methods: Patients with primary knee OA (n = 300) and healthy individuals (n = 300) were examined for rs3761548 and rs2232365 FOXP3 gene polymorphisms by the polymerase chain reaction-restriction fragment-length polymorphism method. The 600 bp promoter region (between -500 and +100) of the gene was also sequenced with direct sequencing in 50 knee OA patients and 50 healthy individuals. Results: There were no sequence variants in the promoter region tested both in OA patients and healthy controls. The SNP rs2232365 showed no association with OA susceptibility and severity and the results of other genetic models were also nonsignificant. On the other hand, rs3761548 AC (P = 0.003), AA + CC (P = 0.0014) as well as AC + AA (P = 0.40) genotypes showed association with Grade 4 knee OA patients. Conclusion: Our findings indicated that the association between FOXP3 rs2232365 polymorphism and knee OA tended to yield negative results but the FOXP3 rs3761548 C allele was associated with elevated risk of OA in Grade 4 knee OA patients in a Turkish population.
dc.description.sponsorshipCumhuriyet University of Scientific Research Projects Commission (CUBAP) of Turkey [T-702]
dc.description.sponsorshipThis study was funded by a grant from Cumhuriyet University of Scientific Research Projects Commission (CUBAP) of Turkey (project number: T-702).
dc.identifier.doi10.1111/1756-185X.13337
dc.identifier.endpage1786
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue10
dc.identifier.pmid30168273
dc.identifier.scopus2-s2.0-85053250944
dc.identifier.scopusqualityQ3
dc.identifier.startpage1779
dc.identifier.urihttps://doi.org/10.1111/1756-185X.13337
dc.identifier.urihttps://hdl.handle.net/11480/15331
dc.identifier.volume21
dc.identifier.wosWOS:000451434000005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Rheumatic Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectOsteoarthritis
dc.subjectFOXP3
dc.subjectPolymorphism
dc.subjectPromoter
dc.subjectTurkish population
dc.titleFOXP3 rs3761548 polymorphism is associated with knee osteoarthritis in a Turkish population
dc.typeArticle

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