Vkorc1 gene polymorphisms confer resistance to anticoagulant rodenticide in Turkish rats

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dc.contributor.authorYigit, Nuri
dc.contributor.authorDuman, Mustafa T.
dc.contributor.authorCetinturk, Derya
dc.contributor.authorSaygili-Yigit, Fulya
dc.contributor.authorColak, Ercument
dc.contributor.authorColak, Reyhan
dc.date.accessioned2024-11-07T13:32:44Z
dc.date.available2024-11-07T13:32:44Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractMutations in Exon 1, 2 and 3 of the vitamin K epoxide reductase complex subunit 1 (Vkorc1) gene are known to lead to anticoagulant rodenticide resistance. In order to investigate their putative resistance in rodenticides, we studied the genetic profile of the Vkorc1 gene in Turkish black rats (Rattus rattus) and brown rats (Rattus norvegicus). In this context, previously recorded Ala21Thr mutation (R. rattus) in Exon 1 region, Ile90Leu mutation (R. rattus, R. norvegicus) in Exon 2 region and Leu120Gln mutation (R. norvegicus) in Exon 3 region were identified as missense mutationscausing amino acid changes. Ala21Thr mutation was first detected in one specimen of Turkish black rat despite the uncertainty of its relevance to resistance. Ile90Leu mutation accepted as neutral variant was detected in most of black rat specimens. Leu120Gln mutation related to anticoagulant rodenticide resistance was found in only one brown rat specimen. Furthermore, Ser74Asn, Gln77Pro (black rat) and Ser79Pro (brown rat) mutations that cause amino acid changes in the Exon 2 region but unclear whether they cause resistance were identified. In addition, silent mutationswhich do not cause amino acid changes were also defined; these mutations were Arg12Arg mutation in Exon 1 region, His68His, Ser81Ser, Ile82Ile and Leu94Leu mutations in Exon 2 region and Ile107Ile, Thr137Thr, Ala143Ala and Gln152Gln mutations in Exon 3 region. These silent mutations were found in both species except for Ser81Ser which was determined in only brown rats.
dc.description.sponsorshipAnkara University Scientific Research Projects Coordination Unit [18B0430005]
dc.description.sponsorshipFunding This study was supported by the Ankara University Scientific Research Projects Coordination Unit (Project no: 18B0430005) . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.identifier.doi10.7717/peerj.15055
dc.identifier.issn2167-8359
dc.identifier.pmid37151288
dc.identifier.scopus2-s2.0-85158894407
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.7717/peerj.15055
dc.identifier.urihttps://hdl.handle.net/11480/15577
dc.identifier.volume11
dc.identifier.wosWOS:000996511200006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPeerj Inc
dc.relation.ispartofPeerj
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectVkorc1
dc.subjectAnticoagulant resistance
dc.subjectMutation
dc.subjectBlack rat
dc.subjectBrown rat
dc.titleVkorc1 gene polymorphisms confer resistance to anticoagulant rodenticide in Turkish rats
dc.typeArticle

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