Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome

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dc.contributor.authorTas, Ayca
dc.contributor.authorHayta, Emrullah
dc.contributor.authorKaradag, Ahmet
dc.contributor.authorZontul, Cemile
dc.contributor.authorOzmen, Esma
dc.contributor.authorAydin, Suleyman
dc.contributor.authorSilig, Yavuz
dc.date.accessioned2024-11-07T13:35:14Z
dc.date.available2024-11-07T13:35:14Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAlthough there is not yet full clarity of the pathogenesis of fibromyalgia syndrome (FM), central sensitization is considered to be responsible. The purpose of this study was to measure the plasma levels of potassium ion channel proteins (human KCNH2, KCNH6 and KCNH7) in FM patients and healthy control subjects. The study sample includes 76 newly diagnosed FM patients and 79 healthy individuals. Venous blood samples were taken to measure the plasma levels of KCNH2, KCNH6 and KCNH7. Pain severity in FM patients was assessed using a visual analog scale (VAS). Bioinformatics analysis was performed using the STRING v 11 Protein interaction tool. Age, gender and body mass index were seen to be similar in both groups. In comparisons between FM and control groups, KCNH2 plasma levels was found to be significantly lower in the FM group. No significant correlation was found between plasma levels of KCNH2, KCNH6 and KCNH7 protein levels and VAS score of patients with FM. The KCNH2 protein had a high homology score with 9 proteins. The plasma levels of KCNH2 FM patients were found to be lower than those of the healthy control subjects, no difference was determined in respect of the plasma levels of KCNH6 and KCNH7. These results may be of use in guiding future studies on the pathogenesis of FM. Copyright: (c) 2021 by the C.M.B. Association. All rights reserved.
dc.description.sponsorshipscientific research project fund of Sivas Cumhuriyet University [SBF-67, T-656]
dc.description.sponsorshipThis study was supported by the scientific research project fund of Sivas Cumhuriyet University (projects no: SBF-67 and T-656).
dc.identifier.doi10.14715/cmb/2021.67.5.57
dc.identifier.endpage457
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue5
dc.identifier.pmid35818223
dc.identifier.scopus2-s2.0-85124946827
dc.identifier.scopusqualityQ4
dc.identifier.startpage451
dc.identifier.urihttps://doi.org/10.14715/cmb/2021.67.5.57
dc.identifier.urihttps://hdl.handle.net/11480/16404
dc.identifier.volume67
dc.identifier.wosWOS:000752871500025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherC M B Assoc
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectPotassium ion channel
dc.subjectfibromyalgia
dc.subjectKCNH2, KCNH6 and KCNH7
dc.titlePotassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome
dc.typeArticle

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