The impact of hyperthyroidism on sexual functions in men and women: a systematic review and meta-analysis

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dc.authoridCihan, Ahmet/0000-0001-5586-8673
dc.contributor.authorCihan, Ahmet
dc.contributor.authorEsen, Ahmet Adil
dc.date.accessioned2024-11-07T13:32:01Z
dc.date.available2024-11-07T13:32:01Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThis study aimed to review the current knowledge on sexual dysfunction in men and women with hyperthyroidism through a systematic review and meta-analysis. Available clinical trials from the MEDLINE database were searched using a prerecorded protocol (Protocol Prospero ID: CRD42022340587), and obtained data were analyzed and reported according to the PRISMA guidelines. Pooled effect estimates were computed using a random-effects model. Twenty eligible studies were identified, of which 15 were included in this meta-analysis. The prevalence of erectile dysfunction was significantly higher in participants with hyperthyroidism than that in controls [odds ratio = 9.16 (95% confidence interval [CI], 5.0-16.5)]. Treatment of hyperthyroidism alone improved erectile functions [effect size, ES = 0.36 (95% CI, -0.01-72)] and mean intra-vaginal ejaculation latency time [ES = 0.63 (95% CI, 0.27-98)] among men with erectile dysfunction and/or premature ejaculation. The prevalence of premature ejaculation also decreased with treatment of hyperthyroidism [odds ratio = 0.11 (95% CI, 0.04-28). Women with hyperthyroidism demonstrated higher odds in female sexual dysfunction than controls [odds ratio = 4.34 (95% CI, 2.63-7.18)]. Female sexual function index scores in women with hyperthyroidism were also significantly lower than those in the controls with moderate effect sizes. An evident and reversible disruption of sexual functions under hyperthyroidism conditions was observed in both sexes.
dc.description.sponsorshipWe would like to thank Mr Osman Demir, a librarian, who supported us during our search for this report. Knowing that we cannot repay our debt to them, we would also like to thank again the 40 rats who were sacrificed for our thesis work in 2008 for the for
dc.description.sponsorshipWe would like to thank Mr Osman Demir, a librarian, who supported us during our search for this report. Knowing that we cannot repay our debt to them, we would also like to thank again the 40 rats who were sacrificed for our thesis work in 2008 for the formation of knowledge and development of sexual medicine on this subject, which could have one basis for this paper.
dc.identifier.doi10.1038/s41443-023-00777-3
dc.identifier.endpage347
dc.identifier.issn0955-9930
dc.identifier.issn1476-5489
dc.identifier.issue4
dc.identifier.pmid37864086
dc.identifier.scopus2-s2.0-85174638510
dc.identifier.scopusqualityQ2
dc.identifier.startpage339
dc.identifier.urihttps://doi.org/10.1038/s41443-023-00777-3
dc.identifier.urihttps://hdl.handle.net/11480/15159
dc.identifier.volume36
dc.identifier.wosWOS:001087912800002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofInternational Journal of Impotence Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectErectile Dysfunction
dc.subjectPremature Ejaculation
dc.subjectDepressive Symptoms
dc.subjectUnited-States
dc.subjectPrevalence
dc.subjectValidation
dc.subjectHypothyroidism
dc.subjectDisorders
dc.subjectHealth
dc.subjectIndex
dc.titleThe impact of hyperthyroidism on sexual functions in men and women: a systematic review and meta-analysis
dc.typeReview Article

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