Protective effect of melatonin on cisplatin induced acute kidney injury: Role of regulation of heat shock proteins expressions

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dc.authoridCEYLAN, TAYFUN/0000-0002-0917-0378
dc.contributor.authorAkin, Ali Tugrul
dc.contributor.authorUnsal, Murat
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorKaymak, Emin
dc.contributor.authorOzturk, Emel
dc.contributor.authorKuloglu, Nurhan
dc.contributor.authorKarabulut, Derya
dc.date.accessioned2024-11-07T13:35:16Z
dc.date.available2024-11-07T13:35:16Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractChemotherapy is one of the major treatment approaches for cancer, and these agents are known to cause severe side effects, including damaging vital organs. Cisplatin (CP) is a commonly used chemotherapeutic agent in the treatment of many cancer types, particularly lung, breast, ovarian, testicular and head-neck cancers. CP is reported to cause damage to damage on brain, kidney, liver and gonads. In this study, is we investigated the protective effects of melatonin (MEL) in acute kidney injury (AKI) induced by CP via assessment of heat-shock protein (HSP) induction in rats. For this purpose, total 40 Wistar albino rats were divided into four groups: Control (n=10), MEL (n=10, 10 mg/kg/i.p. melatonin for 8 days), CP (n=10, 7 mg/kg/i.p. cisplatin at the 5th day), and CP+MEL (n=10, 10 mg/kg/i.p. melatonin for 8 days and 7 mg/kg/i.p. cisplatin at the 5th day). After kidney tissues were extracted, histopathological changes were evaluated and immunoreactivities of HSP47, HSP60, HSP70 and HSP90 in renal cortex were detected via immunohistochemistry. Moreover, blood serum BUN (blood urea nitrogen), creatinine and uric acid levels were measured to assess kidney function. CP group showed histopathological deterioration, and MEL treatment attenuated this damage in CP+MEL group. An increase in HSPs immunoreactivities were detected in renal cortex of CP group when compared with the control and MEL groups, showing increased HSP response because of CP-induced AKI. However, CP-induced HSP induction was significantly lower in the CP+MEL group. Similarly, blood serum BUN, creatinine and uric acid levels were higher in CP group while CP+MEL group showed decreased levels of these parameters. Our results suggest that MEL could exert a significant protective effect against CP-induced AKI via reducing HSP response.
dc.description.sponsorshipErciyes University; research and technology department of Erciyes University
dc.description.sponsorshipThis research was partially supported by Erciyes University. The cost of experimental animals used in this study has been supported by a grant from the research and technology department of Erciyes University.
dc.identifier.doi10.56042/ijeb.v61i09.5135
dc.identifier.endpage696
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue9
dc.identifier.startpage687
dc.identifier.urihttps://doi.org/10.56042/ijeb.v61i09.5135
dc.identifier.urihttps://hdl.handle.net/11480/16423
dc.identifier.volume61
dc.identifier.wosWOS:001066512100004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherNatl Inst Science Communication-Niscair
dc.relation.ispartofIndian Journal of Experimental Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectCancer chemotherapy
dc.titleProtective effect of melatonin on cisplatin induced acute kidney injury: Role of regulation of heat shock proteins expressions
dc.typeArticle

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