Novel method for trisomy 21 screening in the first trimester of pregnancy: fetal brain angle

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dc.authoridcakmak, bulent/0000-0002-1298-6140
dc.contributor.authorKarsli, Mehmet Fatih
dc.contributor.authorCakmak, Bulent
dc.contributor.authorSen, Cihat
dc.date.accessioned2024-11-07T13:34:08Z
dc.date.available2024-11-07T13:34:08Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjectives The present study was performed to examine the utility of a new first trimester marker called the brain angle (BA) in screening for trisomy 21. We postulate that differences in the midbrain anatomy between euploid fetuses and those that are affected by trisomy 21 are reflected in changes in BA measurements. Methods In fetuses at 11(+0)-13(+6) weeks of gestations, which were at high risk for trisomy 21, the angle was measured between the line crossing the thalamus and mesencephalon cranial border tangentially and the line crossing the brainstem lower limit. This angle was compared between fetuses with trisomy 21 (based on karyotyping) and those with a normal karyotype. Results Trisomy 21 was detected in 45 (8%) of 560 fetuses. Receiver operating characteristic analysis showed that, at BA >= 94 degrees, the sensitivity and specificity for determining trisomy 21 were 97.8% (95% CI=88.2-99.9%) and 100% (95% CI=99.2-100%), respectively. Conclusions Fetal BA appears to be a promising new first trimester marker in screening for trisomy 21.
dc.identifier.doi10.1515/jpm-2021-0072
dc.identifier.endpage86
dc.identifier.issn0300-5577
dc.identifier.issn1619-3997
dc.identifier.issue1
dc.identifier.pmid34333886
dc.identifier.scopus2-s2.0-85123650481
dc.identifier.scopusqualityQ2
dc.identifier.startpage82
dc.identifier.urihttps://doi.org/10.1515/jpm-2021-0072
dc.identifier.urihttps://hdl.handle.net/11480/15822
dc.identifier.volume50
dc.identifier.wosWOS:000812328200013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofJournal of Perinatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectangle
dc.subjectmidbrain
dc.subjectscreening
dc.subjecttrisomy 21
dc.titleNovel method for trisomy 21 screening in the first trimester of pregnancy: fetal brain angle
dc.typeArticle

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