Nonionic nontoxic antimicrobial polymers: indole-grafted poly(vinyl alcohol) with pendant alkyl or ether groups

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dc.authoridZhang, Baozhong/0000-0002-7308-1572
dc.authoridLi, Xiaoya/0000-0003-1797-7398
dc.authoridIlk, Sedef/0000-0002-6754-792X
dc.contributor.authorLi, Xiaoya
dc.contributor.authorIlk, Sedef
dc.contributor.authorLiu, Yang
dc.contributor.authorRaina, Deepak Bushan
dc.contributor.authorDemircan, Deniz
dc.contributor.authorZhang, Baozhong
dc.date.accessioned2024-11-07T13:35:12Z
dc.date.available2024-11-07T13:35:12Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractA series of new nonionic antimicrobial polymers with a biodegradable polyvinyl alcohol (PVA) backbone grafted with indole units and different hydrophobic alkyl or ether groups were synthesized by facile esterification. The chemical structures and thermal properties of the obtained polymers were characterized by GPC, NMR, FTIR, WAXD, TGA and DSC analyses. All these nonionic polymers showed a significant antibacterial effect similar to gentamicin against 9 food and human pathogenic bacteria according to the disk diffusion assay. The presence of alkyl or ether groups in most cases did not significantly affect the antibacterial effect compared to the polymer with unsubstituted indole units (with N-H moieties). The impacts of the OH conversion and molecular weight of the obtained polymers on their antimicrobial and anti-quorum sensing effects were also preliminarily investigated. Finally, the obtained indole-grafted PVAs were subjected to MTT assay using a mammalian cell line and hemolysis investigations, and the results showed excellent biocompatibility, particularly for those with ether substituents.
dc.description.sponsorshipMistra Foundation (the STEPS project) [2016/1489]; Swedish Research Council for Sustainable Development (Formas) [202101107]; Carl-Trygger Foundation [18:435]; Guangzhou Elite Education Program; Royal Physiographic Society in Lund
dc.description.sponsorshipThis work was financially supported by the Mistra Foundation (the STEPS project, No. 2016/1489), Swedish Research Council for Sustainable Development (Formas, No. 202101107), Carl-Trygger Foundation (No. 18:435), Guangzhou Elite Education Program, and Royal Physiographic Society in Lund. We thank Maria Del Carmen Casado Munoz at KTH and Laura Quinn at University College Dublin for the help in supplying the strains Escherichia coli ATCC 8739 and Pseudomonas fluorescens (PCL 1701), respectively.
dc.identifier.doi10.1039/d1py01504d
dc.identifier.endpage2319
dc.identifier.issn1759-9954
dc.identifier.issn1759-9962
dc.identifier.issue16
dc.identifier.scopus2-s2.0-85128362360
dc.identifier.scopusqualityQ1
dc.identifier.startpage2307
dc.identifier.urihttps://doi.org/10.1039/d1py01504d
dc.identifier.urihttps://hdl.handle.net/11480/16376
dc.identifier.volume13
dc.identifier.wosWOS:000776778500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofPolymer Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectOf-The-Art
dc.subjectHyperbranched Polymers
dc.subjectAntibacterial Activity
dc.subjectEnzymatic Degradation
dc.subjectChemical-Modification
dc.subjectPolyesters
dc.subjectCoatings
dc.subjectChitosan
dc.subjectPolyelectrolytes
dc.subjectDerivatives
dc.titleNonionic nontoxic antimicrobial polymers: indole-grafted poly(vinyl alcohol) with pendant alkyl or ether groups
dc.typeArticle

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