Physcion and Physcion 8-O-?-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities

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dc.authoridAsrar, Mudassir/0000-0001-5190-6169
dc.authoridShah, Muhammad Ajmal/0000-0003-3471-184X
dc.authoridRiaz, Ammara/0000-0001-5025-9182
dc.contributor.authorAdnan, Muhammad
dc.contributor.authorRasul, Azhar
dc.contributor.authorHussain, Ghulam
dc.contributor.authorShah, Muhammad Ajmal
dc.contributor.authorSarfraz, Iqra
dc.contributor.authorNageen, Bushra
dc.contributor.authorRiaz, Ammara
dc.date.accessioned2024-11-07T13:35:03Z
dc.date.available2024-11-07T13:35:03Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractNature has provided prodigious reservoirs of pharmacologically active compounds for drug development since times. Physcion and physcion 8-O-beta-D-glucopyranoside (PG) are bioactive natural anthraquinones which exert anti-inflammatory and anticancer properties with minimum or no adverse effects. Moreover, physcion also exhibits anti-microbial and hepatoprotective properties, while PG is known to have anti-sepsis as well as ameliorative activities against dementia. This review aims to highlight the natural sources and anticancer activities of physcion and PG, along with associated mechanisms of actions. On the basis of the literature, physcion and PG regulate multitudinous cell signaling pathways through the modulation of various regulators of cell cycle, protein kinases, microRNAs, transcriptional factors, and apoptosis linked proteins resulting in the effective killing of cancerous cells in vitro as well as in vivo. Both compounds effectively suppress metastasis, furthermore, physcion acts as an inhibitor of 6PGD and also plays an important role in chemosensitization. This review article suggests that physcion and PG are potent anticancer drug candidates, but further investigations on their mechanism of action and pre-clinical trials are mandatory in order to comprehend the full potential of these natural cancer killers in anticancer remedies.
dc.description.sponsorshipNagai Foundation Tokyo, Japan [NFT-R-2018]; NRPU [8381/Punjab/NRPU/RD/HEC/2017, 8382/Punjab/NRPU/RD/HEC/2017]
dc.description.sponsorshipThis study is done under the support of The Nagai Foundation Tokyo, Japan (NFT-R-2018) and NRPU Research Grants (8381/Punjab/NRPU/R&D/HEC/2017, 8382/Punjab/NRPU/R&D/HEC/2017).
dc.identifier.doi10.2174/1389450121999201013154542
dc.identifier.endpage504
dc.identifier.issn1389-4501
dc.identifier.issn1873-5592
dc.identifier.issue5
dc.identifier.pmid33050858
dc.identifier.scopus2-s2.0-85104171247
dc.identifier.scopusqualityQ2
dc.identifier.startpage488
dc.identifier.urihttps://doi.org/10.2174/1389450121999201013154542
dc.identifier.urihttps://hdl.handle.net/11480/16311
dc.identifier.volume22
dc.identifier.wosWOS:000627418900002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Drug Targets
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectPhyscion
dc.subjectphyscion 8-O-beta-D-glucopyranoside
dc.subjectnatural products
dc.subjectanthraquinone
dc.subjectanticancer
dc.subjectchemosensitization
dc.titlePhyscion and Physcion 8-O-?-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities
dc.typeReview Article

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