Identification of potential microRNA markers related to Crimean-Congo hemorrhagic fever disease

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dc.authoridCosgun, Yasemin/0000-0002-3815-8036
dc.authoridOZBILUM SAHIN, NIL/0000-0002-2889-3600
dc.authoridBayyurt, Burcu/0000-0002-5618-457X
dc.authoridSari, Ismail/0000-0003-3732-2102
dc.authoridArslan, Serdal/0000-0002-3921-8061
dc.contributor.authorArslan, Serdal
dc.contributor.authorEngin, Aynur
dc.contributor.authorAydemir, Eylem Itir
dc.contributor.authorSahin, Nil Ozbilum
dc.contributor.authorBayyurt, Burcu
dc.contributor.authorSari, Ismail
dc.contributor.authorCosgun, Yasemin
dc.date.accessioned2024-11-07T13:33:01Z
dc.date.available2024-11-07T13:33:01Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractCrimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease caused by the arbovirus Crimean-Congo hemorrhagic fever virus (CCHFV). The CCHFV has a single-stranded RNA genome of negative sense. MicroRNAs (miRNAs) are key players in virus-host interactions and viral pathogenesis. We investigated the miRNA gene expression profiles in patients with CCHF using microarray for the first time in the world. Microarray analysis was performed using mirBase Ver 21 (Agilent Technologies, Santa Clara, CA). All statistical analyses were performed across the case-control, fatal-control, and fatal-nonfatal case groups using Genespring (Ver 3.0). Fifteen miRNAs were statistical significant in patients with CCHF compared with the controls (5 were upregulated, 10 were downregulated). Seventy-five and sixty-six miRNAs are in fatal compared with control and nonfatal case, respectively (fold change ([FC] >= 50) were statistically significant. In this study, the target genes of important miRNAs were identified and Gene Ontology analyses were performed across all groups. As a result of this study, we propose that the detection of miRNAs in patients with CCHF will allow the determination of therapeutic targets in diseases. CCHF is an important public health problem that can often be fatal. In this study, we investigated miRNA expression in case-control, fatal-control, and fatal-nonfatal case groups. Significant miRNAs associated with fatality were detected in CCHF. This study will serve as a source of data for the development of an antagomir-based therapy against CCHF using miRNAs in the future.
dc.description.sponsorshipTUBITAK [115S044]; Scientific and Technological Research Council of Turkey [1001-115S373]
dc.description.sponsorshipTUBITAK, Grant/Award Number: 115S044; The Scientific and Technological Research Council of Turkey, Grant/Award Number: 1001-115S373
dc.identifier.doi10.1002/jcb.28817
dc.identifier.endpage15517
dc.identifier.issn0730-2312
dc.identifier.issn1097-4644
dc.identifier.issue9
dc.identifier.pmid31044455
dc.identifier.scopus2-s2.0-85069514822
dc.identifier.scopusqualityQ2
dc.identifier.startpage15506
dc.identifier.urihttps://doi.org/10.1002/jcb.28817
dc.identifier.urihttps://hdl.handle.net/11480/15744
dc.identifier.volume120
dc.identifier.wosWOS:000476804200122
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Cellular Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectCrimean-Congo hemorrhagic fever
dc.subjectgene expression
dc.subjectmicroarray
dc.subjectmicroRNA
dc.subjectreal-time polymerase chain reaction
dc.titleIdentification of potential microRNA markers related to Crimean-Congo hemorrhagic fever disease
dc.typeArticle

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