The effects of synthetic organoselenium compounds on nitric oxide in DMBA - induced rat liver

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dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorBayraktar, Nihayet
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorGok, Yetkin
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2009
dc.departmentNiğde ÖHÜ
dc.description.abstractDMBA (7,12-dimethylbenz[a]anthracene) is known to generate DNA-reactive species during their metabolism, which may enhance oxidative stress in cells. Since selenium is known as a non-enzymic antioxidant, health problems induced by many environmental pollutants, have stimulated the evaluation of relative antioxidant potential of selenium and synthetic organoselenium compounds. Therefore, we aimed to evaluate chemopreventive potential of synthetic organoselenium compounds by monitoring level of liver nitric oxide. In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds (Se I) and (Se II) in the determined doses. DMBA-induced in rats, the effects of organoselenium compounds on nitric oxide levels in rat liver was studied. In this study, it has been observed a statistically significant increase in (Nitric Oxide) levels for the liver of rat exposed to DMBA (p<0.05). However with administration of Se I and Se II there was a statistically significant decrease in NO levels (p<0.05). The ability of the organoselenium compounds to prevent oxidative damage induced by DMBA in rat livers was rationalized. Protection against nitric oxide measured in Se I and Sell treated groups were provided by synthesized organoselenium compounds. Se I and Sell both provided chemoprevention against DMBA-induced oxidative stress in rat liver.
dc.description.sponsorshipTechnological and Scientific Research Council of Turkey [TUBITAK TBAG-2259 (102T185)]
dc.description.sponsorshipWe thank to Technological and Scientific Research Council of Turkey TUBITAK TBAG-2259 (102T185) for financial support of this work.
dc.identifier.endpage593
dc.identifier.issn0254-8704
dc.identifier.issue4
dc.identifier.pmid20120501
dc.identifier.startpage591
dc.identifier.urihttps://hdl.handle.net/11480/5047
dc.identifier.volume30
dc.identifier.wosWOS:000267957000020
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherTRIVENI ENTERPRISES
dc.relation.ispartofJOURNAL OF ENVIRONMENTAL BIOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDMBA
dc.subjectLiver
dc.subjectNitric oxide
dc.subjectRat and synthetic organoselenium compounds
dc.titleThe effects of synthetic organoselenium compounds on nitric oxide in DMBA - induced rat liver
dc.typeArticle

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