Curcumol: From Plant Roots to Cancer Roots

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dc.authoridWatanabe, Nobumoto/0000-0002-2130-1334
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.contributor.authorWei, Wei
dc.contributor.authorRasul, Azhar
dc.contributor.authorSadiqa, Ayesha
dc.contributor.authorSarfraz, Iqra
dc.contributor.authorHussain, Ghulam
dc.contributor.authorNageen, Bushra
dc.contributor.authorLiu, Xintong
dc.date.accessioned2024-11-07T13:35:05Z
dc.date.available2024-11-07T13:35:05Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractNatural products, an infinite treasure of bioactive scaffolds, have provided an excellent reservoir for the discovery of drugs since millennium. These naturally occurring, biologically active and therapeutically effective chemical entities have emerged as novel paradigm for the prevention of various diseases. This review aims to give an update on the sources as well as pharmacological profile of curcumol, a pharmacologically active sesquiterpenoid, which is an imperative bioactive constituent of several plants mainly from genus Curcuma. Curcumol has potential to fight against cancer, oxidative stress, neurodegeneration, microbial infections, and inflammation. Curcumol has been documented as potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-kappa B which are generally deregulated in several cancers. The reported data reveals multitarget activity of curcumol in cancer treatment suggesting its importance as anticancer drug in future. It is speculated that curcumol may provide an excellent opportunity for the cure of cancer but further investigations on mechanism of its action and preclinical trials are still mandatory to further validate the potential of this natural cancer killer in anticancer therapies.
dc.description.sponsorshipMinistry of Science and Technology, China [2016YFE0128500]; Jilin Provincial Science and Technology Department [20170204009YY, 20180414057GH]; Changchun Science & Technology Department, China [17YJ001, 17YJ006]; Jilin Province Development and Reform Commission [2016C048-3, 2016C047-3]; National Natural Science Foundation of China [31870758]; University S & T Innovation Platform of Jilin Province for Economic Fungi [2014B-1]; Program for Introducing Talents to Universities [B07017]; Nagai Foundation Tokyo, Japan [NFT-R4-2017, NFT-R-2018]; TWAS-COMSTECH Research Grant [17-180 RG/PHA/AS_C]; NRPU Research Grants [8381/Punjab/NRPU/R D/HEC/2017, 8382/Punjab/NRPU/R D/HEC/2017]
dc.description.sponsorshipThis study was supported by the Ministry of Science and Technology, China (No. 2016YFE0128500), Jilin Provincial Science and Technology Department (20170204009YY, 20180414057GH), Changchun Science & Technology Department, China (17YJ001; 17YJ006); Jilin Province Development and Reform Commission(2016C048-3; 2016C047-3), National Natural Science Foundation of China (No. 31870758), University S & T Innovation Platform of Jilin Province for Economic Fungi (#2014B-1), the Program for Introducing Talents to Universities (No. B07017), The Nagai Foundation Tokyo, Japan (NFT-R4-2017; NFT-R-2018), TWAS-COMSTECH Research Grant (No._17-180 RG/PHA/AS_C) and NRPU Research Grants (8381/Punjab/NRPU/R& D/HEC/2017, 8382/Punjab/NRPU/R& D/HEC/2017). We would also like to thank Higher Education Commission (HEC), Pakistan for providing access to related papers from various journals.
dc.identifier.doi10.7150/ijbs.34716
dc.identifier.endpage1609
dc.identifier.issn1449-2288
dc.identifier.issue8
dc.identifier.pmid31360103
dc.identifier.scopus2-s2.0-85069533134
dc.identifier.scopusqualityQ1
dc.identifier.startpage1600
dc.identifier.urihttps://doi.org/10.7150/ijbs.34716
dc.identifier.urihttps://hdl.handle.net/11480/16333
dc.identifier.volume15
dc.identifier.wosWOS:000478085900004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIvyspring Int Publ
dc.relation.ispartofInternational Journal of Biological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectAnticancer
dc.subjectBiological activities
dc.subjectCurcumol
dc.subjectNatural products
dc.titleCurcumol: From Plant Roots to Cancer Roots
dc.typeReview Article

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