Cucurbits plants: A key emphasis to its pharmacological potential

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dc.contributor.authorSalehi B.
dc.contributor.authorCapanoglu E.
dc.contributor.authorAdrar N.
dc.contributor.authorCatalkaya G.
dc.contributor.authorShaheen S.
dc.contributor.authorJaffer M.
dc.contributor.authorAntolak H.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2019
dc.departmentNiğde ÖHÜ
dc.description.abstractCucurbita genus has received a renowned interest in the last years. This plant species, native to the Americas, has served worldwide folk medicine for treating gastrointestinal diseases and intestinal parasites, among other clinical conditions. These pharmacological effects have been increasingly correlated with their nutritional and phytochemical composition. Among those chemical constituents, carotenoids, tocopherols, phenols, terpenoids, saponins, sterols, fatty acids, and functional carbohydrates and polysaccharides are those occurring in higher abundance. However, more recently, a huge interest in a class of triterpenoids, cucurbitacins, has been stated, given its renowned biological attributes. In this sense, the present review aims to provide a detailed overview to the folk medicinal uses of Cucurbita plants, and even an in-depth insight on the latest advances with regards to its antimicrobial, antioxidant and anticancer effects. A special emphasis was also given to its clinical effectiveness in humans, specifically in blood glucose levels control in diabetic patients and pharmacotherapeutic effects in low urinary tract diseases. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
dc.description.sponsorshipUniversidade do Porto Istanbul Teknik Üniversitesi Università degli Studi di Napoli Federico II Entomology and Nematology Department, Institute of Food and Agricultural Sciences University of Calcutta Universidad de Concepción Zabol University of Medical Sciences Politechnika Lódzka
dc.description.sponsorshipStudent Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran; bahar.salehi007@gmail.com Faculty of Chemical & Metallurgical Engineering, Food Engineering Department, Istanbul Technical University, 34469 Maslak, Turkey; capanogl@itu.edu.tr (E.C.); catalkaya.gizem@gmail.com (G.C.) Laboratoire de Biotechnologie Végétale et d’Ethnobotanique, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algérie; n.adrar@hotmail.fr Department of Plant Sciences, LCWU, Lahore 54000, Pakistan; shabnum_shaheen78@hotmail.com (S.S.); meh.jaffer@gmail.com (M.J.) G.B. Pant National Institute of Himalayan Environment & Sustainable Development Kosi-Katarmal, Almora 263 643, India; lalitorchid@gmail.com (L.G.); renusuyal04@gmail.com (R.S.) G.B. Pant National Institute of Himalayan Environment & Sustainable Development Garhwal Regional Centre, Srinagar 246174, India; arunjugran@gbpihed.nic.in Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania; calinadaniela@gmail.com Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania; daoana00@gmail.com Mevsim Gida Sanayi ve Soguk Depo Ticaret A.S. (MVSM Foods), Turankoy, Kestel, 16540 Bursa, Turkey; senemkamiloglu87@gmail.com 10 Institute of Fermentation Technology and Microbiology, Lodz University of Technology, Wolczanska 171/173, 90-924 Lodz, Poland; dorota.kregiel@p.lodz.pl (D.K.); hubert.antolak@p.lodz.pl (H.A.); ewelina.pawlikowska@edu.p.lodz.pl (E.P.) 11 Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata 700019, India; surjitsen09@gmail.com (S.S.); krish_paper@yahoo.com (K.A.) 12 Department of Botany, Fakir Chand College, Diamond Harbour, West Bengal 743331, India 13 Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Campus, 51240 Nigde, Turkey; zselamoglu@ohu.edu.tr 14 Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran 15 Department of Pharmacy, Faculty of Pharmacy, University of Concepcion, Concepcion 4070386, Chile 16 LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal; c.fortunae@gmail.com 17 Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan; shfarukh@mail.ru 18 Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal 19 Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal 20 Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy
dc.identifier.doi10.3390/molecules24101854
dc.identifier.issn1420-3049
dc.identifier.issue10
dc.identifier.pmid31091784
dc.identifier.scopus2-s2.0-85066093697
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.3390/molecules24101854
dc.identifier.urihttps://hdl.handle.net/11480/1571
dc.identifier.volume24
dc.identifier.wosWOS:000470996600012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherMDPI AG
dc.relation.ispartofMolecules
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnticancer
dc.subjectAntimicrobial
dc.subjectAntioxidant
dc.subjectCucurbits
dc.subjectPumpkin
dc.subjectSquash
dc.subjectTraditional medicine
dc.titleCucurbits plants: A key emphasis to its pharmacological potential
dc.typeReview Article

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