Benign nodules of the thyroid gland and 25-hydroxy-vitamin D levels in euthyroid patients

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dc.authoridBolat, Haci/0000-0001-9481-7756
dc.contributor.authorBolat, Haci
dc.contributor.authorErdogan, Aliriza
dc.date.accessioned2024-11-07T13:24:34Z
dc.date.available2024-11-07T13:24:34Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBACKGROUND: The presence of nodules in the thyroid gland is common in iodine-deficient areas of the world. Recently, vitamin D levels were found to be lower than normal and sometimes deficient in malignant nodules of the thyroid. OBJECTIVE: Evaluate the relationship between the serum vitamin D levels and benign thyroid nodules in euthyroid patients. DESIGN: Cross-sectional. SETTING: Tertiary care center in Turkey. PATIENTS AND METHODS: Patients referred to the general surgery outpatient clinic and diagnosed with thyroid nodules were the study group. The control group consisted of healthy individuals without thyroid nodules. Age, BMI, thyroid ultrasonography, serum 25-hydroxyvitamin D, free T3, free T4, thyroid stimulating hormone, calcium, magnesium, phosphorous, total protein, albumin, glucose, creatinine levels and glomerular filtration rate (GFR) were compared between groups. MAIN OUTCOME MEASURE: Serum 25-hydroxy-vitamin D levels and size of the thyroid nodules. SAMPLE SIZE AND CHARACTERISTICS: Of 849 individuals, 453 were patients with thyroid nodules and 396 were healthy individuals. RESULTS: The mean serum vitamin D levels of patients with thyroid nodules were significantly lower than controls (P<.001). Serum vitamin D levels along with serum total protein levels and eGFR were independent variables associated with the presence of a thyroid nodule (P<.001, p=.005 and P=.017, respectively). CONCLUSION: These findings suggest vitamin D deficiency might be one of the pathophysiologic factors in development of thyroid nodules.
dc.identifier.doi10.5144/0256-4947.2022.83
dc.identifier.endpage88
dc.identifier.issn0256-4947
dc.identifier.issn1319-9226
dc.identifier.issue2
dc.identifier.pmid35380060
dc.identifier.scopus2-s2.0-85127502995
dc.identifier.scopusqualityQ3
dc.identifier.startpage83
dc.identifier.urihttps://doi.org/10.5144/0256-4947.2022.83
dc.identifier.urihttps://hdl.handle.net/11480/14175
dc.identifier.volume42
dc.identifier.wosWOS:000788617300003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherK Faisal Spec Hosp Res Centre
dc.relation.ispartofAnnals of Saudi Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectVitamin-D Deficiency
dc.subjectRisk-Factor
dc.subjectCancer
dc.subjectAssociation
dc.subjectManagement
dc.subjectDiagnosis
dc.titleBenign nodules of the thyroid gland and 25-hydroxy-vitamin D levels in euthyroid patients
dc.typeArticle

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