The Effects of Apitherapeutic Agents on Oxidative Stress in Serum Metabolic Parameters of Hypertensive Rats Created by Nitric Oxide Synthase Inhibited

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dc.contributor.authorGulhan, Mehmet Fuat
dc.contributor.authorOzdemir, Betul
dc.contributor.authorSelamoglu, Zeliha
dc.contributor.authorSahna, Engin
dc.date.accessioned2024-11-07T13:34:22Z
dc.date.available2024-11-07T13:34:22Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractHypertension is a chronic disease affecting the whole world due to its clinical effects and complications. The reduction in the release and effect of NO is one of the mechanisms of hypertension formation. Hypertension disrupts the balance between oxidant and antioxidant mechanisms. In this study, we aimed to observe biochemical changes in the blood by treatment propolis, caffeic acid phenethyl ester (CAPE) and pollen in hypertensive rats via Nco-Nitro-L-arginine methyl ester (L-NAME). Rats were divided in five groups. Rats were given L-NAME (40 mg/kg, intraperitoneally) for 14 days to make hypertensive. L-NAME and bee products were administered together with rats for 14 days, then L-NAME for 14 days. All administrated ended 28 days. There was a statistically significant (P<0.05) decrease in blood pressure (BP) in the groups in which bee products were applied. Blood pressure was lower in the pollen treated group than in the CAPE and propolis treated group (P<0.05). Paraoxanase (PON1), total antioxidant status (TAS), total oxidant status (TOS), asymmetric dimethylarginine (ADMA), nuclear factor-kappa B (NF-kappa B) levels were measured in the blood samples in all groups. In the L-NAME group; PON1, TAS, HDL, and total protein levels were found to be lower than the groups applied bee products (P<0.05). TOS, oxidative stress index (OSI), ADMA, NF-kappa B, glucose, cholesterol, LDL, friglyceride, ALT, AST, ALP levels were found to be lower in groups plus of bee products were applied compared to the group that received L-NAME (P<0.05). The results showed that oxidative stress and homeostasis can be regulated with propolis, CAPE and pollen in hypertensive rats induced L-NAME.
dc.description.sponsorshipNigde Omer Halisdemir University (Turkey) Research Fund [BAP 2012/38]
dc.description.sponsorshipWe thank Nigde Omer Halisdemir University (Turkey) Research Fund (Project number: BAP 2012/38) for supporting this work.
dc.identifier.doi10.17576/jsm-2021-5006-20
dc.identifier.endpage1754
dc.identifier.issn0126-6039
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85110243210
dc.identifier.scopusqualityQ2
dc.identifier.startpage1745
dc.identifier.urihttps://doi.org/10.17576/jsm-2021-5006-20
dc.identifier.urihttps://hdl.handle.net/11480/15949
dc.identifier.volume50
dc.identifier.wosWOS:000672277300020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Kebangsaan Malaysia
dc.relation.ispartofSains Malaysiana
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectAsymmetric dimethylarginine
dc.subjectbee products
dc.subjectblood
dc.subjectnuclear factor-kappa B
dc.subjectoxidative stress
dc.subjectparaoxanase
dc.subjectrat
dc.titleThe Effects of Apitherapeutic Agents on Oxidative Stress in Serum Metabolic Parameters of Hypertensive Rats Created by Nitric Oxide Synthase Inhibited
dc.typeArticle

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