Arsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signaling

dc.authoridGul, Alvina/0000-0002-7323-1905
dc.authoridKawano, Tomonori/0000-0002-6876-9399
dc.authoridShahzadi, Andleeb/0000-0003-2082-638X
dc.authoridShahzadi, Andleeb/0000-0002-2774-2325
dc.authoridMetin, Mert/0000-0003-3476-1089
dc.contributor.authorOzturk, Munir
dc.contributor.authorMetin, Mert
dc.contributor.authorAltay, Volkan
dc.contributor.authorBhat, Rouf Ahmad
dc.contributor.authorEjaz, Mahnoor
dc.contributor.authorGul, Alvina
dc.contributor.authorUnal, Bengu Turkyilmaz
dc.date.accessioned2024-11-07T13:35:25Z
dc.date.available2024-11-07T13:35:25Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractArsenic is a well-known element because of its toxicity. Humans as well as plants and animals are negatively affected by its exposure. Some countries suffer from high levels of arsenic in their tap water and soils, which is considered a primary arsenic-linked risk factor for living beings. Humans generally get exposed to arsenic by contaminated drinking waters, resulting in many health problems, ranging from cancer to skin diseases. On the other hand, the FDA-certified drug arsenic trioxide provides solutions for various diseases, including several types of cancers. This issue emphasizes the importance of speciation of the metalloid elements in terms of impacts on health. When species get exposed to arsenic, it affects the cells altering their involvement. It can lead to abnormalities in inflammatory mechanisms and the immune system which contribute to the negative impacts generated on the body. The poisoning originating from arsenic gives rise to various biological signs on the body which can be useful for the diagnosis. It is important to find true biomarkers for the detection of arsenic poisoning. In view of its application in medicine and biology, studies on understanding the biological activity of arsenic have increased. In this review, we aim at summarizing the current state of knowledge of arsenic and the mechanism behind its toxicity including genotoxicity, oxidative insults, epigenomic changes, and alterations in cellular signaling.
dc.identifier.doi10.1007/s12011-021-02719-w
dc.identifier.endpage1001
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue3
dc.identifier.pmid33864199
dc.identifier.scopus2-s2.0-85104751625
dc.identifier.scopusqualityQ1
dc.identifier.startpage988
dc.identifier.urihttps://doi.org/10.1007/s12011-021-02719-w
dc.identifier.urihttps://hdl.handle.net/11480/16498
dc.identifier.volume200
dc.identifier.wosWOS:000640726800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectArsenic
dc.subjectCancer
dc.subjectCell signaling
dc.subjectGenotoxicity
dc.subjectHuman health
dc.titleArsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signaling
dc.typeArticle

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