Effects of the Gut Microbiota and Barrier Function on Melatonin Efficacy in Alleviating Liver Injury

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dc.authoridElsabagh, Mabrouk/0000-0002-0596-6547
dc.authoridMa, Yi/0000-0002-3781-314X
dc.contributor.authorZhang, Hao
dc.contributor.authorLiu, Xiaoyun
dc.contributor.authorElsabagh, Mabrouk
dc.contributor.authorZhang, Ying
dc.contributor.authorMa, Yi
dc.contributor.authorJin, Yaqian
dc.contributor.authorWang, Mengzhi
dc.date.accessioned2024-11-07T13:34:50Z
dc.date.available2024-11-07T13:34:50Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractEnvironmental cadmium (Cd) exposure has been associated with severe liver injury. In contrast, melatonin (Mel) is a candidate drug therapy for Cd-induced liver injury due to its diverse hepatoprotective activities. However, the precise molecular mechanism by which Mel alleviates the Cd-induced liver injury, as well as the Mel-gut microbiota interaction in liver health, remains unknown. In this study, mice were given oral gavage CdCl2 and Mel for 10 weeks before the collection of liver tissues and colonic contents. The role of the gut microbiota in Mel's efficacy in alleviating the Cd-induced liver injury was evaluated by the gut microbiota depletion technique in the presence of antibiotic treatment and gut microbiota transplantation (GMT). Our results revealed that the oral administration of Mel supplementation mitigated liver inflammation, endoplasmic reticulum (ER) stress and mitophagy, improved the oxidation of fatty acids, and counteracted intestinal microbial dysbiosis in mice suffering from liver injury. It was interesting to find that neither Mel nor Cd administration induced any changes in the liver of antibiotic-treated mice. By adopting the GMT approach where gut microbiota collected from mice in the control (CON), Cd, or Mel + Cd treatment groups was colonized in mice, it was found that gut microbiota was involved in Cd-induced liver injury. Therefore, the gut microbiota is involved in the Mel-mediated mitigation of ER stress, liver inflammation and mitophagy, and the improved oxidation of fatty acids in mice suffering from Cd-induced liver injury.
dc.description.sponsorshipfund for the National Natural Science Foundation of China [31902180]; Top Talents Award Plan of Yangzhou University (2020); Yangzhou University
dc.description.sponsorshipThe research was supported by the fund for the National Natural Science Foundation of China (Grant number 31902180), the Top Talents Award Plan of Yangzhou University (2020) and the Cyanine Project of Yangzhou University (2020).
dc.identifier.doi10.3390/antiox11091727
dc.identifier.issn2076-3921
dc.identifier.issue9
dc.identifier.pmid36139801
dc.identifier.scopus2-s2.0-85138535885
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/antiox11091727
dc.identifier.urihttps://hdl.handle.net/11480/16194
dc.identifier.volume11
dc.identifier.wosWOS:000857428700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofAntioxidants
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectcadmium
dc.subjectmelatonin
dc.subjectintestinal microbiota
dc.subjectliver injury
dc.subjectgut microbiota transplantation
dc.titleEffects of the Gut Microbiota and Barrier Function on Melatonin Efficacy in Alleviating Liver Injury
dc.typeArticle

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