Serum interleukin-18 levels are associated with non-dipping pattern in newly diagnosed hypertensive patients

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dc.contributor.authorGunturk, Ertugrul Emre
dc.contributor.authorGunturk, Inayet
dc.contributor.authorTopuz, Ayse Nur
dc.contributor.authorAkkaya, Hasan
dc.contributor.authorTopuz, Mustafa
dc.date.accessioned2024-11-07T13:32:26Z
dc.date.available2024-11-07T13:32:26Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground Interleukin-18 (IL-18), a pro-inflammatory cytokine, increases inflammation in the endothelium. Increased inflammation plays an important role in the development of hypertension (HT). IL-18 level is higher in hypertensives than normotensives. Objective To investigate the relationship between IL-18 level and diurnal blood pressure (BP) variations in newly diagnosed HT patients. Methods This prospective study included 130 subjects referred to outpatient cardiology clinic with an initial diagnosis of HT. The patients were classified as dipper HT (n = 40), non-dipper HT (n = 50), and normotensive (control, n = 40) according to 24-hour ambulatory BP monitoring. All subjects underwent blood sampling after 12 hours of fasting and transthoracic echocardiography. Results The serum IL-18 level was significantly higher in the patient group compared with the controls (195.17 +/- 93.00 mg/dl vs. 140.75 +/- 71.11 mg/dl, P < 0.01) and also in the non-dipper group than in the dipper group (217.3 +/- 96.90 mg/dl, 167.5 +/- 80.79 mg/dl, P = 0.011). IL-18 level was positively correlated both the night-time SBP and DBP levels (r = 0.29, P = 0.02 and r = 0.34, P < 0.01, respectively). On multivariate linear regression analysis, left atrium diameter, left ventricular mass index, and serum IL-18 level were independent predictors of non-dipping pattern in newly diagnosed HT patients. Conclusion Higher IL-18 level was particularly associated with an increase in the night-time BP levels. IL-18 can be used as a predictor for non-dipper HT in newly diagnosed HT patients.
dc.identifier.doi10.1097/MBP.0000000000000487
dc.identifier.endpage92
dc.identifier.issn1359-5237
dc.identifier.issn1473-5725
dc.identifier.issue2
dc.identifier.pmid33038089
dc.identifier.scopus2-s2.0-85102602492
dc.identifier.scopusqualityQ2
dc.identifier.startpage87
dc.identifier.urihttps://doi.org/10.1097/MBP.0000000000000487
dc.identifier.urihttps://hdl.handle.net/11480/15420
dc.identifier.volume26
dc.identifier.wosWOS:000639295000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofBlood Pressure Monitoring
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjecthypertension
dc.subjectinterleukin-18
dc.subjectnon-dipper pattern
dc.titleSerum interleukin-18 levels are associated with non-dipping pattern in newly diagnosed hypertensive patients
dc.typeArticle

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