Association between the soluble epoxide hydrolase gene and preeclampsia

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dc.contributor.authorSari I.
dc.contributor.authorPinarbasi H.
dc.contributor.authorPinarbasi E.
dc.contributor.authorYildiz C.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2017
dc.departmentNiğde ÖHÜ
dc.description.abstractObjective: In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women. Methods: K55R polymorphism and methylation level of the EPHX2 promoter were determined by the real-time PCR using double-dye hydrolysis probes and methylation-sensitive high-resolution melting analysis, respectively. Results: The presence of the K55R polymorphism was significantly higher in cases (28.1%) than controls (17.3%), and was associated with increased risk of PE (OR: 1.86; 95% CI: 1.09–2.63). Methylation levels of the EPHX2 promoter region in cases were significantly lower than controls. A 2.83 times increased PE risk was observed in pregnant women with EPHX2 promoter methylation levels of <25% (OR: 2.83; 95% CI: 1.15–6.91). Conclusion: In conclusion, hypomethylation of the promoter region of EPHX2 and K55R polymorphism were associated with significant increased risk of PE. sEH enzyme may play a role in the pathogenesis of PE by contributing to reduction of the vasodilatator, anti-hypertensive, and anti-inflammatory effects of EETs by rapid degradation of these molecules. © 2017 Taylor & Francis.
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Cumhuriyet University (grant number T-551).
dc.identifier.doi10.1080/10641955.2017.1388390
dc.identifier.endpage325
dc.identifier.issn1064-1955
dc.identifier.issue4
dc.identifier.pmid29058492
dc.identifier.scopus2-s2.0-85031933699
dc.identifier.scopusqualityQ2
dc.identifier.startpage315
dc.identifier.urihttps://dx.doi.org/10.1080/10641955.2017.1388390
dc.identifier.urihttps://hdl.handle.net/11480/1778
dc.identifier.volume36
dc.identifier.wosWOS:000418577600006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofHypertension in Pregnancy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectepoxyeicosatrienoic acid
dc.subjectgenetic polymorphism
dc.subjectmethylation
dc.subjectSoluble epoxide hydrolase
dc.titleAssociation between the soluble epoxide hydrolase gene and preeclampsia
dc.typeArticle

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