Gut microbiota contributes to bisphenol A-induced maternal intestinal and placental apoptosis, oxidative stress, and fetal growth restriction in pregnant ewe model by regulating gut-placental axis

Basit Öğe Kaydı
dc.contributor.authorZhang, Hao
dc.contributor.authorZha, Xia
dc.contributor.authorZhang, Bei
dc.contributor.authorZheng, Yi
dc.contributor.authorElsabagh, Mabrouk
dc.contributor.authorWang, Hongrong
dc.contributor.authorWang, Mengzhi
dc.date.accessioned2024-11-07T13:35:01Z
dc.date.available2024-11-07T13:35:01Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackgroundBisphenol A (BPA) is an environmental contaminant with endocrine-disrupting properties that induce fetal growth restriction (FGR). Previous studies on pregnant ewes revealed that BPA exposure causes placental apoptosis and oxidative stress (OS) and decreases placental efficiency, consequently leading to FGR. Nonetheless, the response of gut microbiota to BPA exposure and its role in aggravating BPA-mediated apoptosis, autophagy, mitochondrial dysfunction, endoplasmic reticulum stress (ERS), and OS of the maternal placenta and intestine are unclear in an ovine model of gestation.ResultsTwo pregnant ewe groups (n = 8/group) were given either a subcutaneous (sc) injection of corn oil (CON group) or BPA (5 mg/kg/day) dissolved in corn oil (BPA group) once daily, from day 40 to day 110 of gestation. The maternal colonic digesta and the ileum and placental tissue samples were collected to measure the biomarkers of autophagy, apoptosis, mitochondrial dysfunction, ERS, and OS. To investigate the link between gut microbiota and the BPA-induced FGR in pregnant ewes, gut microbiota transplantation (GMT) was conducted in two pregnant mice groups (n = 10/group) from day 0 to day 18 of gestation after removing their intestinal microbiota by antibiotics. The results indicated that BPA aggravates apoptosis, ERS and autophagy, mitochondrial function injury of the placenta and ileum, and gut microbiota dysbiosis in pregnant ewes. GMT indicated that BPA-induced ERS, autophagy, and apoptosis in the ileum and placenta are attributed to gut microbiota dysbiosis resulting from BPA exposure.ConclusionsOur findings indicate the underlying role of gut microbiota dysbiosis and gut-placental axis behind the BPA-mediated maternal intestinal and placental apoptosis, OS, and FGR. The findings further provide novel insights into modulating the balance of gut microbiota through medication or probiotics, functioning via the gut-placental axis, to alleviate gut-derived placental impairment or FGR.DorkkcsjvJM4thb48aSHyrVideo AbstractConclusionsOur findings indicate the underlying role of gut microbiota dysbiosis and gut-placental axis behind the BPA-mediated maternal intestinal and placental apoptosis, OS, and FGR. The findings further provide novel insights into modulating the balance of gut microbiota through medication or probiotics, functioning via the gut-placental axis, to alleviate gut-derived placental impairment or FGR.DorkkcsjvJM4thb48aSHyrVideo Abstract
dc.description.sponsorshipProject of National Key Research and Development Program of China [2023YFD1301705]; Top Talents Award Plan of Yangzhou University; Cyanine Project of Yangzhou University
dc.description.sponsorshipThe research was supported by the fund for the Project of National Key Research and Development Program of China (2023YFD1301705), the Top Talents Award Plan of Yangzhou University (2020) and the Cyanine Project of Yangzhou University (2020).
dc.identifier.doi10.1186/s40168-024-01749-5
dc.identifier.issn2049-2618
dc.identifier.issue1
dc.identifier.pmid38365714
dc.identifier.scopus2-s2.0-85185390969
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s40168-024-01749-5
dc.identifier.urihttps://hdl.handle.net/11480/16280
dc.identifier.volume12
dc.identifier.wosWOS:001163635100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofMicrobiome
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectBisphenol A
dc.subjectFetal growth restriction
dc.subjectGut microbiota
dc.subjectGut-placental axis
dc.subjectPregnant ewe
dc.titleGut microbiota contributes to bisphenol A-induced maternal intestinal and placental apoptosis, oxidative stress, and fetal growth restriction in pregnant ewe model by regulating gut-placental axis
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu