Hepato-protective effects of thymoquinone and beta-aminoisobutyric acid in streptozocin induced diabetic rats

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dc.authoridAKTAS, IBRAHIM/0000-0002-0956-8204
dc.authoridGUR, FATIH MEHMET/0000-0001-7748-3272
dc.contributor.authorAktas, Ibrahim
dc.contributor.authorGur, Fatih Mehmet
dc.date.accessioned2024-11-07T13:25:24Z
dc.date.available2024-11-07T13:25:24Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractWe investigated the hepato-protective effects of thymoquinone (TQ) and beta-aminoisobutyric acid (BAIBA). We used five groups of 8-week-old male rats: untreated control group, streptozotocin (STZ) diabetic group, STZ + TQ group, STZ + BAIBA group, and STZ + TQ + BAIBA group. After experimental diabetes mellitus (DM) was established using STZ, TQ was given to the STZ + TQ group, BAIBA to the STZ + BAIBA group, and TQ and BAIBA to the STZ + TQ + BAIBA group. In the STZ group, body weight, relative liver weight, and glutathione, blood albumin and insulin levels were decreased compared to the control. Also, water and food consumption, tumor necrosis factor-alpha expression, malondialdehyde, blood glucose, alanine aminotransferase, aspartate aminotransferase and gamma glutamyl transferase levels were increased the STZ group compared to the control group. In the STZ group, sinusoid congestion and dilation, monocyte and lymphocyte infiltration and microvesicular steatosis were observed in the liver tissue. Pathological changes caused by DM were reduced significantly in the STZ + TQ, STZ + BAIBA and STZ + TQ + BAIBA groups. The protective effect of BAIBA was greater than for TQ; the greatest protective effect was observed following combined use of TQ + BAIBA. We suggest that our findings for the STZ + TQ, STZ + BAIBA and STZ + TQ + BAIBA groups were due to the antioxidant effects of TQ and BAIBA. TQ and BAIBA appear to be potential therapeutic agents for ameliorating hepatic damage due to DM.
dc.description.sponsorshipAdiyaman University Research Center [SHMYOMAP/20180001]
dc.description.sponsorshipThis study was supported by a grant from Adiyaman University Research Center, Project SHMYOMAP/20180001.
dc.identifier.doi10.1080/10520295.2021.1949041
dc.identifier.endpage76
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1
dc.identifier.pmid34281431
dc.identifier.scopus2-s2.0-85110869362
dc.identifier.scopusqualityQ2
dc.identifier.startpage67
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1949041
dc.identifier.urihttps://hdl.handle.net/11480/14683
dc.identifier.volume97
dc.identifier.wosWOS:000675143300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectBeta-aminoisobutyric acid
dc.subjectdiabetes mellitus
dc.subjectliver
dc.subjectrat
dc.subjectstreptozotocin
dc.subjectthymoquinone
dc.titleHepato-protective effects of thymoquinone and beta-aminoisobutyric acid in streptozocin induced diabetic rats
dc.typeArticle

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