T-786C, G894T, and intron 4 VNTR (4a/b) polymorphisms of the endothelial nitric oxide synthase gene in bladder cancer cases

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dc.contributor.authorPolat F.
dc.contributor.authorDiler S.B.
dc.contributor.authorAzazi I.
dc.contributor.authoröden A
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2015
dc.departmentNiğde ÖHÜ
dc.description.abstractThe aim of the present study was to determine whether endothelial nitric oxide synthase (eNOS) gene polymorphisms play a role in development of bladder cancer in the Turkish population. The study was performed on 75 patients (64 men, 11 women) with bladder cancer and 143 healthy individuals (107 men, 36 women) with any kind of cancer history. Three eNOS gene polymorphisms (T-786C promoter region, G894T and intron 4 VNTR 4a/b) were determined with polymerase chain reaction and restriction fragment lenght polymorphism methods. In our study, GT and TT genotypes for eNOS G894T polymorphism were found to significantly vary among patients with bladder cancer and control group (OR: 0.185, CI: 0.078-0.439, p=0.0001 and OR: 0.324, CI: 0.106-0.990, p=0.026). Also, the frequency of the 894T allele was significantly higher in patients with bladder cancer (51%). No association was identified for eNOS T-786C and intron 4 VNTR 4a/b polymorphisms between patients with bladder cancer and control groups in our Turkish population.
dc.identifier.doi10.7314/APJCP.2015.16.6.2199
dc.identifier.endpage2202
dc.identifier.issn1513-7368
dc.identifier.issue6
dc.identifier.pmid25824737
dc.identifier.scopus2-s2.0-84929180151
dc.identifier.scopusqualityQ3
dc.identifier.startpage2199
dc.identifier.urihttps://dx.doi.org/10.7314/APJCP.2015.16.6.2199
dc.identifier.urihttps://hdl.handle.net/11480/1947
dc.identifier.volume16
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBladder cancer
dc.subjecteNOS
dc.subjectPolymorphism
dc.subjectTurkish population
dc.titleT-786C, G894T, and intron 4 VNTR (4a/b) polymorphisms of the endothelial nitric oxide synthase gene in bladder cancer cases
dc.typeArticle

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