Can the long term using of pregabalin in fibromyalgia affect the choroid and retinal nerve fiber layer?

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dc.contributor.authorBicer, Gamze Yildirim
dc.contributor.authorZor, Kursad Ramazan
dc.contributor.authorBicer, Kadir Eren
dc.contributor.authorKucuk, Erkut
dc.contributor.authorKucuk, Esin Benli
dc.date.accessioned2024-11-07T13:32:07Z
dc.date.available2024-11-07T13:32:07Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground In this study, the effects of long-term pregabalin use on the choroid and retinal nerve fiber layer were investigated in the fibromyalgia disease. Methods The patient group consisted of 41 fibromyalgia patients using pregabalin. The control group consisted of 41 newly diagnosed fibromyalgia patients who had not received any treatment yet. Choroidal and retinal nerve fiber layer thickness measurements were performed with Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA, USA) 30 minutes after pupil dilation with 1% tropicamide. Results There was no difference in subfoveal choroidal thickness, nasal choroidal thickness and temporal choroidal thickness between the patient and control groups (p > 0.05). Increasing the duration of drug use within the patient group was found to thin the retinal nerve fiber layer (p < 0.05). Conclusion We found that pregabalin had no effect on the choroid, while it had a thinning effect for retinal nerve fiber layer. It is recommended not to be preferred pregabalin in fibromyalgia patients with retinal nerve fiber layer damage such as diabetic retinopathy and glaucoma. Patients treated with pregabalin should have regular control in the ophthalmology clinic.
dc.identifier.doi10.1038/s41433-021-01864-9
dc.identifier.endpage2322
dc.identifier.issn0950-222X
dc.identifier.issn1476-5454
dc.identifier.issue12
dc.identifier.pmid34857924
dc.identifier.scopus2-s2.0-85120634091
dc.identifier.scopusqualityQ1
dc.identifier.startpage2318
dc.identifier.urihttps://doi.org/10.1038/s41433-021-01864-9
dc.identifier.urihttps://hdl.handle.net/11480/15240
dc.identifier.volume36
dc.identifier.wosWOS:000725404400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofEye
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectThickness
dc.titleCan the long term using of pregabalin in fibromyalgia affect the choroid and retinal nerve fiber layer?
dc.typeArticle

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