The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K ATP channel

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dc.contributor.authorKaya S.T.
dc.contributor.authorBozdogan O.
dc.contributor.authorOzarslan T.O.
dc.contributor.authorTaskin E.
dc.contributor.authorEksioglu D.
dc.contributor.authorErim F.
dc.contributor.authorYasar S.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2019
dc.departmentNiğde ÖHÜ
dc.description.abstractContext: Cardiovascular dysfunctions such as life-threatening arrhythmias are one of the main reasons of mortality and morbidity in diabetic patients Objective: We aimed to investigate the long-term effects of resveratrol, berberine and glibenclamide combinations on the ischemia/reperfusion (I/R) induced arrhythmias in streptozotocin (STZ)-induced diabetic rats and to investigate the role of myocardial K ATP channel in the possible anti-arrhythmic actions of the treatments. Methods: Two days after induction of diabetes, diabetic rats were treated with resveratrol [5 mg/kg, intraperitoneally (i.p.)], berberine (10 mg/kg, i.p) and glibenclamide (5 mg/kg, i.p) for 6 weeks. On the 43th day, experimental animals were subjected to 6-min ischemia and 6-min reperfusion in vivo. Results: The protein expression of Kir6.2 subunits was downregulated in the diabetic hearts. However, all drug treatments restored the protein expression of Kir6.2 subunits. Resveratrol alone and its combination with glibenclamide decreased the arrhythmia score, the arrhythmic period and the incidence of other types of arrhythmias during the reperfusion period. Conclusions: The combination of resveratrol with glibenclamide may alleviate reperfusion-induced arrhythmias via an underlying mechanism not be only associated with the restoration of the protein expression of Kir6.2 subunits but also associated with the other subunits or ion channels underlying cardiac action potential. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
dc.description.sponsorshipFundamental Research Fund of Shandong University Abant Izzet Baysal Üniversitesi
dc.description.sponsorshipWe would like to thank Abant Izzet Baysal University Research Fund for supporting the study [Project No.: 2015.03.01.823].
dc.identifier.doi10.1080/13813455.2018.1440409
dc.identifier.endpage121
dc.identifier.issn1381-3455
dc.identifier.issue2
dc.identifier.pmid29457517
dc.identifier.scopus2-s2.0-85042231178
dc.identifier.scopusqualityQ2
dc.identifier.startpage114
dc.identifier.urihttps://dx.doi.org/10.1080/13813455.2018.1440409
dc.identifier.urihttps://hdl.handle.net/11480/1500
dc.identifier.volume125
dc.identifier.wosWOS:000462366900003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectarrhythmias
dc.subjectDiabetes
dc.subjectglibenclamide
dc.subjectmyocardial KATP channel
dc.subjectresveratrol
dc.titleThe protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K ATP channel
dc.typeArticle

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