Extraction of mandelic acid with tri-octyl-phosphine oxide (TOPO) in different solvents: Equilibrium and neural network analysis

Basit Öğe Kaydı
dc.contributor.authorKiris, Baris
dc.contributor.authorUslu, Hasan
dc.contributor.authorSantos, Dheiver
dc.contributor.authorKiris, Sinem Buyuksaatci
dc.contributor.authorAsci, Yavuz Selim
dc.date.accessioned2024-11-07T13:34:18Z
dc.date.available2024-11-07T13:34:18Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractMandelic acid is an important carboxylic acid used in pharmaceutical industries. It is also important to use it as a purified form. In this study, selective extraction of mandelic acid was done by tri-octyl-phosphine oxide (TOPO) diluted in different solvents such as methyl isobutyl ketone, 1-octanol, octyl acetate, dimethyl phthalate, 2-octanone, cyclohexane and toluene. The high selectivity of mandelic acid from aqueous solution was supported by thermodynamic parameters (loading factor, distribution coefficient, and extraction efficiency). The obtained values for each solvent were applied to the Neural Network Analysis to predict phase equilibrium behaviour in ternary systems. The results showed the highest mandelic acid extraction efficiency (93.65 %) and distribution coefficient (14.74) were attained with the organic phase mixture prepared with MIBK and TOPO. Also, it was found that extraction efficiencies increased with increasing TOPO amount in the medium for all studied solvents.
dc.identifier.doi10.1016/j.jics.2024.101412
dc.identifier.issn0019-4522
dc.identifier.issue11
dc.identifier.scopus2-s2.0-85205722819
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1016/j.jics.2024.101412
dc.identifier.urihttps://hdl.handle.net/11480/15913
dc.identifier.volume101
dc.identifier.wosWOS:001334032000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of the Indian Chemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectMandelic acid
dc.subjectTri-octyl-phosphine oxide
dc.subjectNeural network
dc.subjectSolvent
dc.titleExtraction of mandelic acid with tri-octyl-phosphine oxide (TOPO) in different solvents: Equilibrium and neural network analysis
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu