Synthesis and biological studies of novel hydroxyacetophenone-tetrazole hybrids

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dc.authoridDilek, Gulay/0000-0001-6562-2554
dc.contributor.authorDisli, Ali
dc.contributor.authorYucesoy, Esin Eylem
dc.contributor.authorOzturk, Ali
dc.contributor.authorDilek, Gulay
dc.date.accessioned2024-11-07T13:34:28Z
dc.date.available2024-11-07T13:34:28Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractA series of novel hybrid compounds was synthesized where 2 '-hydroxyacetophenone and N-alkylated thiotetrazole were coupled via methylene spacers of different lengths. The structures of the compounds were characterized by spectroscopic techniques, including the 1H-and 13C-NMR, FT-IR, and HRMS methods. The antimicrobial activities of the title compounds were evaluated against clinical isolates of Gram-positive and negative bacterial and fungal species. All compounds showed a broad spectrum of antimicrobial activity and inhibited all bacteria and fungi that tested with MIC values ranging from 4 to 128 mu g/ml. 4a and 5d were the most active antibacterial members.
dc.identifier.doi10.25135/acg.oc.148.2302.2696
dc.identifier.endpage86
dc.identifier.issn1307-6175
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85165066333
dc.identifier.scopusqualityQ4
dc.identifier.startpage75
dc.identifier.urihttps://doi.org/10.25135/acg.oc.148.2302.2696
dc.identifier.urihttps://hdl.handle.net/11480/15997
dc.identifier.volume16
dc.identifier.wosWOS:000984238300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAcg Publications
dc.relation.ispartofOrganic Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectHydroxyacetophenone
dc.subjecttetrazole
dc.subjecthybrid
dc.titleSynthesis and biological studies of novel hydroxyacetophenone-tetrazole hybrids
dc.typeArticle

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