Role of Synthesized Organoselenium Compounds on Protection of Rat Erythrocytes from DMBA-Induced Oxidative Stress

Basit Öğe Kaydı
dc.authorid0000-0002-4551-8650
dc.authorid0000-0001-6080-229X
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorAtes, Burhan
dc.contributor.authorGok, Yetkin
dc.contributor.authorCetinkaya, Bekir
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2009
dc.departmentNiğde ÖHÜ
dc.description.abstractFormation of free radicals is not limited to normal cellular process but also occur upon exposure to certain chemicals (polycyclic aromatic hydrocarbon, cadmium, lead, etc.), cigarette smoke, radiation, and high-fat diet. Free-radical damage is an important factor in many pathological and toxicological processes. Selenium, an essential micronutrient, is a associated with antioxidant functions, physiological defense mechanisms against different diseases including several types of cancers. Search for new selenium compounds with more chemopreventive activities and less toxicities are in progress. In addition, there has been a growing interest in the synthesis of organoselenium compounds with respect to their use in enzymology and bioorganic chemistry. In the present study, adult female Wistar rats were treated with 7,12-dimethylbenz[a]anthracene (DMBA) and the organoselenium compounds [1-isopropyl-3-methylbenzimidazole-2-selenone (Se I) and 1, 3-di-p-methoxybenzylpyrimidine-2-selenone (Se II)] in determined doses. The protective effects of synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in antioxidant enzyme (superoxide dismutase, glutathione peroxidase (GSH-Px), catalase (CAT), glutathione reductase (GR)) activities, total GSH, and malondialdehyde (MDA) levels of rat erythrocyte were investigated. The DMBA-treated group exhibited significant decreases in the levels of erythrocyte GSH-Px, CAT, and GR activities, an increase in MDA levels, and a decrease in total GSH level compared to the control. Se I and Se II fully or partially restored enzyme activity. Lipid peroxidation was also decreased in Se-I- and Se-II-treated groups.
dc.identifier.doi10.1007/s12011-008-8262-0
dc.identifier.endpage175
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2
dc.identifier.pmid18974938
dc.identifier.scopus2-s2.0-65449148261
dc.identifier.scopusqualityQ1
dc.identifier.startpage167
dc.identifier.urihttps://dx.doi.org/10.1007/s12011-008-8262-0
dc.identifier.urihttps://hdl.handle.net/11480/5058
dc.identifier.volume128
dc.identifier.wosWOS:000264463000009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherHUMANA PRESS INC
dc.relation.ispartofBIOLOGICAL TRACE ELEMENT RESEARCH
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectErythrocyte
dc.subjectOxidative stress
dc.subjectRat
dc.subjectSynthetic organoselenium compounds
dc.titleRole of Synthesized Organoselenium Compounds on Protection of Rat Erythrocytes from DMBA-Induced Oxidative Stress
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu