Histological investigations on thymus of male rats prenatally exposed to bisphenol A

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dc.contributor.authorAydemir I.
dc.contributor.authorKum Ş.
dc.contributor.authorTuğlu M.İ.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2018
dc.departmentNiğde ÖHÜ
dc.description.abstractBisphenol A is called as a endocrine-distrupting chemical because of the its steroid-like activity and it used in the construction of plastic containing materials. It is indicated that bisphenol A can pass the human serum, urine, follicular fluid, placenta and umblical cord as a result of the use of substances containing this agent. In this study, we aimed to investigate the effects of bisphenol A on the development of the thymus, a primary lymphoid organ which plays an important role in the specific immunity. The adult pregnant female rats were administered orally with bisphenol A (for 21 days) and postnatal thymus samples were obtained on day 21, 45 and 90 and were performed for histochemical and immunohistochemical staining for CD3, CD4, CD8 and CD79a and TUNEL assay for the apoptotic cells. Evaluation of all groups, CD3, CD4, CD8 and CD79a stainings were decreased in the experimental groups compared with control group. The apoptotic cells were determined in the all groups on day 90 as a result of the thymus involution. It is noted that there was not any histological and morphological damages in the rats prenatally exposed the bisphenol A. The effect of the bisphenol A is unknown in the future, but there is no problem in the adult rats. © 2018 Elsevier Ltd
dc.description.sponsorshipThis study was financially supported by the Scientific Research Committee of Adnan Menderes University (Project number: VTF12022 ).
dc.identifier.doi10.1016/j.chemosphere.2018.04.145
dc.identifier.endpage8
dc.identifier.issn0045-6535
dc.identifier.pmid29723747
dc.identifier.scopus2-s2.0-85046170329
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://dx.doi.org/10.1016/j.chemosphere.2018.04.145
dc.identifier.urihttps://hdl.handle.net/11480/1612
dc.identifier.volume206
dc.identifier.wosWOS:000436215600002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofChemosphere
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBisphenol-A
dc.subjectHistology
dc.subjectT lymphocyte
dc.subjectThymus
dc.titleHistological investigations on thymus of male rats prenatally exposed to bisphenol A
dc.typeArticle

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