Chemical and biological characteristics of propolis from Apis mellifera caucasica from the Ardahan and Erzurum provinces of Turkey: a comparative study

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dc.authoridYildirim, Deniz/0000-0002-5041-8160
dc.authoridSevgiler, Yusuf/0000-0002-4373-2389
dc.contributor.authorArslan, Mehmet
dc.contributor.authorSevgiler, Yusuf
dc.contributor.authorGuven, Celal
dc.contributor.authorMurathan, Zehra Tugba
dc.contributor.authorErbil, Nurcan
dc.contributor.authorYildirim, Deniz
dc.contributor.authorBuyukleyla, Mehmet
dc.date.accessioned2024-11-07T13:35:13Z
dc.date.available2024-11-07T13:35:13Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe aim of this study was to compare the biological activities of ethanolic propolis extracts of Apis mellifera caucasica obtained from Ardahan and Erzurum provinces of Turkey. Samples were tested for antioxidant, anticytotoxic, anticarcinogenic, antibacterial, and antifungal potentials using different techniques. Propolis samples from the two provinces had different mineral and organic compositions related to their geographical origin. The ferric reducing antioxidant power (FRAP) test showed superiority of Ardahan propolis over the Erzurum. Regardless of origin and the presence of mitomycin C in the culture medium, propolis enhanced human peripheral lymphocyte viability, which depended on the duration and propolis concentration. Antiperoxidative activity on MCF-7 breast cancer cells was concentration-dependent. Erzurum propolis showed the highest anticarcinogenic activity at the concentrations of 62.5 mu g/mL and 125 mu g/mL, which dropped at higher concentrations. All propolis samples also showed antibacterial activity against the tested human pathogens similar to ampicillin and penicillin controls, except for Pseudomonas aeruginosa. However, they did not exert any antifungal activity against Candida albicans and Yarrowia lipolytica. In conclusion, propolis samples from both provinces showed promising biological activities, but further research should focus on finding the right concentrations for optimal effect and include the cell necrosis pathway to get a better idea of the anticarcinogenic effects.
dc.description.sponsorshipTurkish Scientific and Technical Research Council (TUBITAK) [116Z049]
dc.description.sponsorshipWe would like to thank the Adiyaman University Central Research Laboratory Application and Research Centre and the Aksaray University Scientific and Technological Application and Research Centre for their technical support. We would also like to thank our healthy blood donors for cytotoxicity tests. This project was supported by the Turkish Scientific and Technical Research Council (TUBITAK) (project no. 116Z049).
dc.identifier.doi10.2478/aiht-2021-72-3492
dc.identifier.endpage69
dc.identifier.issn0004-1254
dc.identifier.issn1848-6312
dc.identifier.issue1
dc.identifier.pmid33787188
dc.identifier.scopus2-s2.0-85103682627
dc.identifier.scopusqualityQ3
dc.identifier.startpage53
dc.identifier.urihttps://doi.org/10.2478/aiht-2021-72-3492
dc.identifier.urihttps://hdl.handle.net/11480/16385
dc.identifier.volume72
dc.identifier.wosWOS:000657362500008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInst Medical Research & Occupational Health
dc.relation.ispartofArhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectanticarcinogen
dc.subjectantimicrobial
dc.subjectbiological activity
dc.subjectmineral
dc.subjectmitomycin C
dc.subjectorganic composition
dc.titleChemical and biological characteristics of propolis from Apis mellifera caucasica from the Ardahan and Erzurum provinces of Turkey: a comparative study
dc.typeArticle

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