Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent

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dc.authorid0000-0002-5463-8355
dc.contributor.authorIlk, Sedef
dc.contributor.authorSaglam, Necdet
dc.contributor.authorOzgen, Mustafa
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2017
dc.departmentNiğde ÖHÜ
dc.description.abstractFlavonoid compounds are strong antioxidant and antifungal agents but their applications are limited due to their poor dissolution and bioavailability. The use of nanotechnology in agriculture has received increasing attention, with the development of new formulations containing active compounds. In this study, kaempferol (KAE) was loaded into lecithin/chitosan nanoparticles (LC NPs) to determine antifungal activity compared to pure KAE against the phytopathogenic fungus Fusarium oxysporium to resolve the bioavailability problem. The influence of formulation parameters on the physicochemical properties of KAE loaded lecithin chitosan nanoparticles (KAE-LC NPs) were studied by using the electrostatic self-assembly technique. KAE-LC NPs were characterized in terms of physicochemical properties. KAE has been successfully encapsulated in LC NPs with an efficiency of 93.8 +/- 4.28% and KAE-LC NPs showed good physicochemical stability. Moreover, in vitro evaluation of the KAE-LC NP system was made by the release kinetics, antioxidant and antifungal activity in a time-dependent manner against free KAE. Encapsulated KAE exhibited a significantly inhibition efficacy (67%) against Fusarium oxysporium at the end of the 60 day storage period. The results indicated that KAE-LC NP formulation could solve the problems related to the solubility and loss of KAE during use and storage. The new nanoparticle system enables the use of smaller quantities of fungicide and therefore, offers a more environmentally friendly method of controlling fungal pathogens in agriculture.
dc.description.sponsorshipHacettepe University Scientific Research Project [014 D12 101 005-820]; Scientific and Technological Research Council of Turkey (TUBITAK) [2211/C]
dc.description.sponsorshipThis work was supported by Hacettepe University Scientific Research Project grant (014 D12 101 005-820) and The Scientific and Technological Research Council of Turkey (TUBITAK) with PhD Scholarship (2211/C).
dc.identifier.doi10.1080/21691401.2016.1192040
dc.identifier.endpage916
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue5
dc.identifier.pmid27265551
dc.identifier.scopus2-s2.0-84976317513
dc.identifier.scopusqualityQ1
dc.identifier.startpage907
dc.identifier.urihttps://dx.doi.org/10.1080/21691401.2016.1192040
dc.identifier.urihttps://hdl.handle.net/11480/3527
dc.identifier.volume45
dc.identifier.wosWOS:000402039400007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntifungal agent
dc.subjectencapsulation
dc.subjectkaempferol
dc.subjectnanoparticle engineering system
dc.subjectplant pathogens
dc.subjectsafe natural
dc.titleKaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent
dc.typeArticle

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