Early and late adverse clinical outcomes of severe carbon monoxide intoxication: A cross-sectional retrospective study

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dc.authoridVURAL, Abdussamed/0000-0003-4506-916X
dc.contributor.authorVural, Abdussamed
dc.contributor.authorDolanbay, Turgut
dc.date.accessioned2024-11-07T13:24:56Z
dc.date.available2024-11-07T13:24:56Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground Carbon monoxide (CO) results from incomplete combustion of carbon-based materials, causing symptoms such as headaches, dizziness, nausea, chest pain, confusion, and, in severe cases, unconsciousness. Normobaric oxygen therapy (NBOT) is the standard therapy, whereas hyperbaric oxygen therapy (HBOT) is recommended in severe cases of organ damage. This study examined the early and late adverse outcomes in patients with severe CO poisoning.Materials and methods This study analyzed severe cases of CO poisoning among patients admitted to the emergency department between January 2020 and May 2022. The demographic, clinical, and laboratory data of symptomatic individuals and those requiring HBOT were examined. The study recorded early outcomes, such as intubation and in-hospital mortality, and late outcomes, such as delayed neurological sequelae and 1-year mortality. Chi-square tests, Spearman's rho correlation tests, and logistic regression analyses were performed to identify factors affecting these outcomes.Results Patients who received HBOT showed a significant difference in delayed neurological sequelae (DNS) compared to those who received NBOT (p = 0.037). Significant differences were observed in the need for intubation, in-hospital mortality, and 1-year mortality between patients based on COHb levels, but no significant differences were found in DNS. The 1-year mortality probability was significantly influenced by COHb level (odds ratio = 1.159, 95% CI [1.056-1.273]). Patients receiving NBOT had a higher odds ratio for DNS risk than those receiving HBOT (odds ratio = 8.464, 95% [1.755-40.817], p = 0.008).Conclusion The study showed no differences in intubation, in-hospital mortality, and 1-year mortality rates between the HBOT and NBOT groups. However, significant differences in DNS suggest that treatment modalities have different effects on neurological outcomes. High COHb levels are associated with an increased risk of intubation, and mortality underscores the significance of monitoring COHb levels in clinical evaluations.
dc.identifier.doi10.1371/journal.pone.0301399
dc.identifier.issn1932-6203
dc.identifier.issue8
dc.identifier.pmid39213322
dc.identifier.scopus2-s2.0-85202946969
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0301399
dc.identifier.urihttps://hdl.handle.net/11480/14403
dc.identifier.volume19
dc.identifier.wosWOS:001304170300009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectLong-Term Mortality
dc.subjectHyperbaric-Oxygen
dc.subjectPrevention
dc.subjectManagement
dc.subjectDiagnosis
dc.subjectSequelae
dc.subjectTime
dc.titleEarly and late adverse clinical outcomes of severe carbon monoxide intoxication: A cross-sectional retrospective study
dc.typeArticle

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