ASSOCIATION OF THE SEH GENE PROMOTER POLYMORPHISMS AND HAPLOTYPES WITH PREECLAMPSIA

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dc.authoridSari, Ismail/0000-0003-3732-2102
dc.contributor.authorSari, Ismail
dc.contributor.authorOkten, Hatice
dc.contributor.authorAktan, Cagdas
dc.contributor.authorCihan, Esra
dc.date.accessioned2024-11-07T13:31:21Z
dc.date.available2024-11-07T13:31:21Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground: The epoxyeicosatrienoic acids (EETs) have antihypertensive, anti-inflammatory, and organ protective properties and their circulation levels are related to hypertension, diabetes mellitus, cardiovascular diseases, and preeclampsia. Soluble epoxide hydrolase (sEH) catalyses the degradation of EETs to less biologically active dihydroxyeicosatrienoic acids. Here, we sequenced the promoter region of EPHX2 to investigate the association between promoter sequence alterations that we thought to affect the expression levels of the enzyme and preeclampsia (PE). Methods: Nucleotide sequencing of the promoter region of the EPHX2, spanning from position -671 to +30, was performed on 100 pregnant women with PE and, 20 or more weeks pregnant normotensive, healthy women (n=100). Results: Pregnant women who carry rs4149235, rs4149232, rs73227309, and rs62504268 polymorphisms have 4.4, 2.4, 2.3, and 2.8 times significantly increased risk of PE, respectively. CCGG (OR: 3.11; 95% CI: 1.12-8.62) and CCCA (OR: 0.45; 95% CI: 0.36-0.55) haplotypes were associated with an increased and decreased risk of PE, respectively. Conclusions: Four SNPs (rs4149232, rs4149235, rs73227309, and rs62504268) in the promoter region of the EPHX2, and CCGG and CCCA haplotypes of these 4 SNPs were significantly associated with PE. These SNPs in the promoter region may affect sEH expression and enzyme activity and may play a role in PE pathogenesis by causing individual differences in EET levels. However, future studies are needed to confirm our findings and examine the effect of these SNPs on the sEH expression and/or enzyme activity.
dc.description.sponsorshipScientific Research Project Fund of Sivas Cumhuriyet University [T-658]
dc.description.sponsorshipWe are thankful to all the study participants for their contribution. This work was supported by the Scientific Research Project Fund of Sivas Cumhuriyet University under project number T-658.
dc.identifier.doi10.5937/jomb0-27745
dc.identifier.endpage435
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.issue4
dc.identifier.pmid33312058
dc.identifier.scopus2-s2.0-85099127497
dc.identifier.scopusqualityQ3
dc.identifier.startpage428
dc.identifier.urihttps://doi.org/10.5937/jomb0-27745
dc.identifier.urihttps://hdl.handle.net/11480/14796
dc.identifier.volume39
dc.identifier.wosWOS:000575084800003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoc Medical Biochemists Serbia
dc.relation.ispartofJournal of Medical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectepoxyeicosatrienoic acids
dc.subjectpreeclampsia
dc.subjectsoluble epoxide hydrolase
dc.subjectpolymorphism
dc.subjectgene promoter
dc.titleASSOCIATION OF THE SEH GENE PROMOTER POLYMORPHISMS AND HAPLOTYPES WITH PREECLAMPSIA
dc.title.alternativeVeza izmedu preeklampsije i polimorfizama sEH promotera gena i haplotipova
dc.typeArticle

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