Comparative developmental toxicity evaluation of di-n-hexyl phthalate and dicyclohexyl phthalate in rats

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dc.authoridBarlas, Nurhayat/0000-0001-8657-2058
dc.contributor.authorAhbab, Muefide Aydogan
dc.contributor.authorGuven, Celal
dc.contributor.authorKockaya, Evrim Arzu
dc.contributor.authorBarlas, Nurhayat
dc.date.accessioned2024-11-07T13:34:42Z
dc.date.available2024-11-07T13:34:42Z
dc.date.issued2017
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractTo investigate the effects of di-n-hexyl phthalate (DHP) and dicyclohexyl phthalate (DCHP) on the development of fetus and placenta in utero, pregnant rats were exposed to DHP or DCHP at dosages of 0, 20, 100, and 500 mg/kg bw/day, by gavage, on gestational days 6-19. Anogenital distance (AGD) and AGD-body weight(1/3) ratio of female fetuses decreased in all treatment groups in a non-dose-response way. The ossification centers of bones and the intensity of Alizarin red stain of the fetuses decreased in all treatment groups. The white blood cell levels of fetuses in DHP and DCHP exposed groups increased at all dosages. Mean cell hemoglobin, hemoglobin concentrations, and hemoglobin levels of all DHP and DCHP treated male and female fetuses were reduced. Histopathologic changes (hemorrhage in labyrinth, degeneration of spongiotrophoblast, hemorrhage, decreased and irregular vessel formation, and edema in the basal zone) were observed in placentas at high dosages of DHP and DCHP. In contrast, there was no change in weight gain of dams in DHP and DCHP exposed groups compared to control, but resorption rate, reduced fetal weight, delayed ossification, placental disruption, and hematologic parameters clearly indicated that in utero DHP and DCHP exposure resulted in intrauterine growth retardation in rats.
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK) [SBAG-3106 105S073]
dc.description.sponsorshipThis study was supported by Scientific and Technical Research Council of Turkey (TUBITAK) (project no: SBAG-3106 105S073). The immunohistochemical stainings of placental sections were conducted in Department of Biophysics, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
dc.identifier.doi10.1177/0748233717711868
dc.identifier.endpage716
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue9
dc.identifier.pmid28854868
dc.identifier.scopus2-s2.0-85029042364
dc.identifier.scopusqualityQ3
dc.identifier.startpage696
dc.identifier.urihttps://doi.org/10.1177/0748233717711868
dc.identifier.urihttps://hdl.handle.net/11480/16129
dc.identifier.volume33
dc.identifier.wosWOS:000410998600004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectDi-n-hexyl phthalate
dc.subjectdicyclohexyl phthalate
dc.subjectplacenta
dc.subjectossification of bones
dc.subjectIUGR
dc.subjectin utero
dc.titleComparative developmental toxicity evaluation of di-n-hexyl phthalate and dicyclohexyl phthalate in rats
dc.typeArticle

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