Protective Effects of Hypericum perforatum and Quercetin in a Rat Model of Ischemia/Reperfusion Injury of Testes

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dc.authoridAktas, Serdar/0000-0003-3243-8093
dc.contributor.authorSuzen, Alev
dc.contributor.authorTekin, Leyla
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorErturk, Nazile
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorAktas, Serdar
dc.date.accessioned2024-11-07T13:34:42Z
dc.date.available2024-11-07T13:34:42Z
dc.date.issued2018
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose This study aimed to compare the protective effects of Hypericum perforatum (Hp) and quercetin, a flavonoid, against ischemia/reperfusion (I/R) injury in rat testes. Materials and Methods This study included 28 male Wistar albino rats that were divided into four groups. Except for the sham group, torsion was created by rotating both testes at an angle of 720 degrees clockwise for 2 hours. The Hp and quercetin groups received 25 mg/kg Hp and quercetin intraperitoneally 30 minutes before detorsion, respectively. Orchiectomy was performed for the measurement of markers of oxidative stress and histopathological examination. Results In the Hp and quercetin groups, malondialdehyde (MDA) and nitric oxide (NO) levels and total oxidant capacity were significantly lower, the glutathione level and total antioxidant status were significantly higher, and Johnsen's testis biopsy scores were significantly higher than in the torsion/detorsion group (p=0.001). The markers of oxidative injury were significantly lower (p=0.001) and total antioxidant status was significantly higher (p=0.001), except for glutathione (p=0.62) in the Hp group than in the quercetin group. Johnsen's score between Hp and quercetin groups was not significantly different (p=0.80). Conclusion Both Hp and quercetin have protective effects against I/R injury of the testes, but the protective effect of Hp was found to be stronger than that of quercetin.
dc.identifier.doi10.1055/s-0037-1604397
dc.identifier.endpage100
dc.identifier.issn0939-7248
dc.identifier.issn1439-359X
dc.identifier.issue1
dc.identifier.pmid28837999
dc.identifier.scopus2-s2.0-85028341904
dc.identifier.scopusqualityQ2
dc.identifier.startpage96
dc.identifier.urihttps://doi.org/10.1055/s-0037-1604397
dc.identifier.urihttps://hdl.handle.net/11480/16133
dc.identifier.volume28
dc.identifier.wosWOS:000422934200016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofEuropean Journal of Pediatric Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjecttestis torsion
dc.subjectHypericum perforatum
dc.subjectquercetin
dc.titleProtective Effects of Hypericum perforatum and Quercetin in a Rat Model of Ischemia/Reperfusion Injury of Testes
dc.typeArticle

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