Evaluation of the Association of Serum Sclerostin and Carotid Intima Media Thickness with Chronic Kidney Failure and Kidney Transplantation

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dc.contributor.authorKeskiner, Ozlem Oguz
dc.contributor.authorOzturk, Yasin
dc.contributor.authorOzer, Hakan
dc.contributor.authorBaloglu, İsmail
dc.contributor.authorUysal, Saliha
dc.contributor.authorToker, Aysun
dc.contributor.authorKeskin, Suat
dc.date.accessioned2024-11-07T10:40:04Z
dc.date.available2024-11-07T10:40:04Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose: This study aimed to determine the serum sclerostin levels in kidney transplant recipients, dialysis patients, and patients with non-dialysis chronic kidney disease (CKD), and evaluate their associations with carotid intima-media thickness (CIMT) and carotid artery plaque presence. Methods: The study groups included kidney transplant recipients (n = 61), dialysis patients (n = 43), non-dialysis CKD patients (n = 43), and healthy controls (n = 19). Serum sclerostin levels were measured by the ELISA method. All participants underwent imaging tests for the evaluations of CIMT and carotid plaque presence. Results: Serum sclerostin levels were highest in dialysis patients, followed by the non-dialysis CKD group. Kidney transplant patients and healthy controls had the lowest sclerostin levels. There was a positive correlation between CIMT and sclerostin levels in the CKD group. Sclerostin levels were significantly high in individuals with calcified plaques. Conclusion: The CIMT and serum sclerostin levels of kidney transplant recipients compared to those of CKD patients with and without dialysis may suggest that transplantation may prevent further atherosclerosis, with sclerostin levels promising a predictive role. © 2024, Taiwan Society of Geriatric Emergency & Critical Care Medicine.
dc.description.sponsorshipScientific Research Projects Commission, (161518020)
dc.identifier.doi10.6890/IJGE.202407_18(3).0002
dc.identifier.endpage149
dc.identifier.issn1873-9598
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85200358663
dc.identifier.scopusqualityQ4
dc.identifier.startpage144
dc.identifier.urihttps://doi.org/10.6890/IJGE.202407_18(3).0002
dc.identifier.urihttps://hdl.handle.net/11480/11408
dc.identifier.volume18
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaiwan Society of Geriatric Emergency and Critical Care Medicine (TSGECM)
dc.relation.ispartofInternational Journal of Gerontology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectcarotid intima-media thickness
dc.subjectchronic
dc.subjectheart disease risk factors
dc.subjectkidney transplantation
dc.subjectrenal insufficiency
dc.subjectsclerostin
dc.titleEvaluation of the Association of Serum Sclerostin and Carotid Intima Media Thickness with Chronic Kidney Failure and Kidney Transplantation
dc.typeArticle

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