Pharmacoinformatics approaches in the discovery of drug-like antimicrobials of plant origin

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dc.authoridGul, Alvina/0000-0002-7323-1905
dc.contributor.authorKhan, Duaa Ahmad
dc.contributor.authorHamdani, Syed Damin Abbas
dc.contributor.authorIftikhar, Sahar
dc.contributor.authorMalik, Sohaib Zafar
dc.contributor.authorZaidi, Najam-us-Sahar Sadaf
dc.contributor.authorGul, Alvina
dc.contributor.authorBabar, Mustafeez Mujtaba
dc.date.accessioned2024-11-07T13:34:55Z
dc.date.available2024-11-07T13:34:55Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractMedicinal plants have served as an important source for addressing the ailments of humans and animals alike. The emergence of advanced technologies in the field of drug discovery and development has helped in isolating various bioactive phytochemicals and developing them as drugs. Owing to their significant pharmacological benefits and minimum adverse effects, they not only serve as good candidates for therapeutics themselves but also help in the identification and development of related drug like molecules against various metabolic and infectious diseases. The ever-increasing diversity, severity and incidence of infectious diseases has resulted in an exaggerated mortality and morbidity levels. Geno-proteomic mutations in microbes, irrational prescribing of antibiotics, antimicrobial resistance and human population explosion, all call for continuous efforts to discover and develop alternated therapeutic options against the microbes. This review article describes the pharmacoinformatics tools and methods which are currently used in the discovery of bioactive phytochemicals, thus making the process more efficient and effective. The pharmacological aspects of the drug discovery and development process have also been reviewed with reference to the in silico activities. Communicated by Ramaswamy H. Sarma
dc.identifier.doi10.1080/07391102.2021.1894982
dc.identifier.endpage7628
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.issue16
dc.identifier.pmid33663347
dc.identifier.scopus2-s2.0-85138127790
dc.identifier.scopusqualityQ2
dc.identifier.startpage7612
dc.identifier.urihttps://doi.org/10.1080/07391102.2021.1894982
dc.identifier.urihttps://hdl.handle.net/11480/16240
dc.identifier.volume40
dc.identifier.wosWOS:000625670500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Biomolecular Structure & Dynamics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAntimicrobial discovery
dc.subjecthigh-throughput screening
dc.subjectmedicinal plants
dc.subjectpharmacoinformatics
dc.subjectphytochemicals
dc.titlePharmacoinformatics approaches in the discovery of drug-like antimicrobials of plant origin
dc.typeArticle

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