Protective effects of silymarin against paclitaxel-induced cardiac toxicity

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dc.authoridAKTAS, IBRAHIM/0000-0002-0956-8204
dc.authoridBilgic, Sedat/0000-0001-8410-2685
dc.authoridMartinez, Jose/0000-0002-0177-4847
dc.authoridGUR, FATIH MEHMET/0000-0001-7748-3272
dc.contributor.authorAktas, Ibrahim
dc.contributor.authorGur, Fatih Mehmet
dc.contributor.authorMartinez, Jose L.
dc.contributor.authorBilgic, Sedat
dc.contributor.authorKorkoca, Hanifi
dc.date.accessioned2024-11-07T13:34:15Z
dc.date.available2024-11-07T13:34:15Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIn this study, the protectivity of silymarin (SY) against the harmful effects of paclitaxel (PX) on the heart was investigated. PX was administered 2 mg/kg intraperitoneally to the PX group, 100 mg/kg SY was administered by gavage to the SY group, and both drugs were administered to the PX + SY group as other groups. Treatment with SY significantly decreased cardiac troponin I (cTn-I), brain natriuretic peptide (BNP), creatine kinase isoenzyme MB (CK-MB) and lactate dehydrogenase (LDH) levels. In the PX group; the decrease in glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) levels and the increase in malondialdehyde (MDA) levels were significantly normalized with SY administration. Histologically; heart injury was significantly reduced in the PX + SY group compared to the PX group. As a result, it was determined that SY, which has antioxidant, anti-apoptotic and anti-inflammatory effects, could protect the heart tissue from the toxic effects of PX.
dc.identifier.doi10.37360/blacpma.24.23.5.47
dc.identifier.endpage759
dc.identifier.issn0717-7917
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85195312636
dc.identifier.scopusqualityQ3
dc.identifier.startpage749
dc.identifier.urihttps://doi.org/10.37360/blacpma.24.23.5.47
dc.identifier.urihttps://hdl.handle.net/11480/15862
dc.identifier.volume23
dc.identifier.wosWOS:001234153100002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMs-Editions
dc.relation.ispartofBoletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectHeart damage
dc.subjectPaclitaxel
dc.subjectRat
dc.subjectSilymarin
dc.subjectOxidative stress
dc.titleProtective effects of silymarin against paclitaxel-induced cardiac toxicity
dc.title.alternativeEfectos protectores de silymarin contra toxicidad cardiaca inducida por paclitaxel
dc.typeArticle

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