The relationship between FGF23 and anemia in HD and renal transplant patients

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dc.authoridOZER, Hakan/0000-0001-9174-0351
dc.authoridOZTURK, YASIN/0000-0003-2634-2677
dc.authoridTurkmen, Kultigin/0000-0002-1667-7716
dc.contributor.authorBaloglu, Ismail
dc.contributor.authorOzer, Hakan
dc.contributor.authorOzturk, Yasin
dc.contributor.authorErdur, Mehmet Fatih
dc.contributor.authorTonbul, Halil Zeki
dc.contributor.authorTurkmen, Kultigin
dc.date.accessioned2024-11-07T13:34:49Z
dc.date.available2024-11-07T13:34:49Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose Recent studies claim that FGF23 is also associated with anemia and inflammation. In this study, the relationship between FGF23 and anemia in hemodialysis (HD) and renal transplantation patients (RTx patients) patients was investigated. Methods This was a cross-sectional study involving 40 RTx patients (13 females, 27 males; mean age, 45.93 +/- 12.49 years) who had transplantation at least 6 months before, 25 HD patients (12 females, 13 males; mean age, 54.72 +/- 15.5 years), and 20 healthy control subjects (13 females, 7 males; mean age, 36.7 +/- 9.38 years). FGF23 was studied using Elisa method. Parameters such as iron, ferritin, total iron binding capacity, and transferrin saturation were assessed. Results FGF23 level was significantly higher in HD patients when compared with the RTx patients and control groups. In the bivariate correlation analysis, hemoglobin was positively correlated with albumin (r = 0.681, p = 0.000), ferritin (r = 0.446, p = 0.043), and negatively correlated with CRP (r = - 0.476, p = 0.016) and FGF23 (r = 0.493, p = 0.043). FGF23 was found to be an independent predictor of decreased hemoglobin in HD patients. In addition, this association was observed to disappear after transplantation. Conclusion While FGF23 is closely related to hemoglobin levels in HD patients, we have shown that this relationship disappears after transplantation.
dc.identifier.doi10.1007/s11255-021-02982-9
dc.identifier.endpage1122
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue5
dc.identifier.pmid34482498
dc.identifier.scopus2-s2.0-85114173033
dc.identifier.scopusqualityQ2
dc.identifier.startpage1117
dc.identifier.urihttps://doi.org/10.1007/s11255-021-02982-9
dc.identifier.urihttps://hdl.handle.net/11480/16184
dc.identifier.volume54
dc.identifier.wosWOS:000693349900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectFGF23
dc.subjectAnemia
dc.subjectHemodialysis
dc.subjectRenal transplantation
dc.titleThe relationship between FGF23 and anemia in HD and renal transplant patients
dc.typeArticle

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