Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Discriminating Precancerous Pathologies from Cervical Cancer

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dc.authoridYAVUZ, ADEM/0000-0003-4191-4004
dc.authoridAk, Mehmet/0000-0003-3384-0586
dc.authoridTas, Mustafa/0000-0001-7183-0026
dc.contributor.authorTas, Mustafa
dc.contributor.authorYavuz, Adem
dc.contributor.authorAk, Mehmet
dc.contributor.authorOzcelik, Bulent
dc.date.accessioned2024-11-07T13:34:18Z
dc.date.available2024-11-07T13:34:18Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose. We aimed to determine the predictive value of several hematological markers of inflammation on the presence/absence of cervical cancer and also to determine their ability in discriminating precancerous cervical pathologies from cervical cancer. Materials and Methods. In this study, patients who presented to Acibadem Kayseri Hospital between May 2010 and June 2018 were evaluated. Forty patients with low-grade squamous intraepithelial lesions (LSIL), 40 patients with high-grade squamous intraepithelial lesions (HSIL), and 30 patients with cervical cancer (CC) were retrospectively included in this study. A control group of 70 healthy volunteers with normal cervical cytology was also included in the study. Results. The neutrophil-to-lymphocyte ratio (NLR) was significantly higher in patients with CC than in controls. The platelet-to-lymphocyte ratio (PLR) was significantly higher in patients with CC compared to those with LSIL and HSIL diagnoses and also controls (p<0.001). Logistic regression analysis revealed that age (OR: 1.075, 95% CI: 1.020-1.132, p=0.007), NLR (OR: 1.643, 95% CI: 1.009-3.142, p=0.047), and PLR (OR: 1.032, 95% CI: 1.003-1.062, p=0.029) were predictors for the presence of CC. ROC curve analysis revealed that both NLR and PLR were predictive of CC with a cutoff value of 2.02 for NLR (71% sensitivity and 60% specificity, AUC: 0.682, p=0.004) and 126.7 for PLR (83% sensitivity and 69% specificity, AUC: 0.752, p<0.001). Conclusion. In addition to patients' age, determination of NLR and PLR values, which are simple, inexpensive, and readily available markers of systemic inflammation, may help in decision making precancerous pathologies of the cervix.
dc.identifier.doi10.1155/2019/2476082
dc.identifier.issn1687-8450
dc.identifier.issn1687-8469
dc.identifier.pmid31558903
dc.identifier.scopus2-s2.0-85072370564
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/2019/2476082
dc.identifier.urihttps://hdl.handle.net/11480/15914
dc.identifier.volume2019
dc.identifier.wosWOS:000486413600002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofJournal of Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectPretreatment Neutrophil
dc.subjectPreoperative Neutrophil
dc.subjectNutritional-Status
dc.subjectPredicts Survival
dc.subjectOvarian-Cancer
dc.subjectGrowth-Factor
dc.subjectNeutrophil/Lymphocyte
dc.subjectResection
dc.subjectRelease
dc.subjectRisk
dc.titleNeutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Discriminating Precancerous Pathologies from Cervical Cancer
dc.typeArticle

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