Biochemical changes induced by grape seed extract and low level laser therapy administration during intraoral wound healing in rat liver: an experimental and in silico study

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dc.authoridEkhteiari Salmas, Ramin/0000-0003-3888-5070
dc.authoridDurdagi, Serdar/0000-0002-0426-0905
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorSalmas, Ramin Ekhteiari
dc.contributor.authorDurdagi, Serdar
dc.contributor.authorAkgul, Hasan
dc.contributor.authorDemirkol, Mehmet
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorSelamoglu, Zeliha
dc.date.accessioned2024-11-07T13:35:17Z
dc.date.available2024-11-07T13:35:17Z
dc.date.issued2018
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIn the present study, the changes that occur in rat liver tissue as a result of the use of grape seed extract (GSE) and low level laser therapy (LLLT) in intraoral wound (IW) healing are analyzed using biochemical parameters. Diode laser application groups received 8J/cm(2) dose LLLT once a day for 4days (810nm wavelength, continuous mode, 0.25W, 9s). As a result of the biological parameter analysis, it was determined that the oxidative damage caused by the IWs and recovery period on 7th and 14th days could be substantially removed with GSE applications that have antioxidant capacity especially in rat liver tissue. In addition, the active compound of grape seed, catechin is studied in the active site of glycogen synthase kinase 3 (GSK3) target using molecular modeling approaches. Post-processing molecular dynamics (MD) results for catechin is compared with a standard GSK3 inhibitor. MD simulations assisted for better understanding of inhibition mechanism and the crucial amino acids contributing in the ligand binding. These results along with a through free energy analysis of ligands using sophisticated simulations methods are quite striking and it suggests a greater future role for simulation in deciphering complex patterns of molecular mechanism in combination with methods for understanding drug-receptor interactions.
dc.identifier.doi10.1080/07391102.2017.1305297
dc.identifier.endpage1008
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.issue4
dc.identifier.pmid28279122
dc.identifier.scopus2-s2.0-85017147653
dc.identifier.scopusqualityQ2
dc.identifier.startpage993
dc.identifier.urihttps://doi.org/10.1080/07391102.2017.1305297
dc.identifier.urihttps://hdl.handle.net/11480/16431
dc.identifier.volume36
dc.identifier.wosWOS:000427724300014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Biomolecular Structure & Dynamics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectLow level laser therapy
dc.subjectintraoral wound healing
dc.subjectoxidative stress
dc.subjectgrape seed extract
dc.subjectliver
dc.subjectrat
dc.subjectmolecular modeling
dc.subjectmolecular docking
dc.subjectinduced fit docking
dc.subjectMM-PBSA
dc.subjectmolecular dynamics (MD) simulations
dc.titleBiochemical changes induced by grape seed extract and low level laser therapy administration during intraoral wound healing in rat liver: an experimental and in silico study
dc.typeArticle

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