Analysis of serum cytokine and protective vitamin D levels in severe cases of COVID-19

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dc.authoridERDOGDU, HAMZA/0000-0002-5025-2367
dc.authoridBayraktar, Mehmet/0000-0003-2306-6531
dc.contributor.authorBayraktar, Nihayet
dc.contributor.authorTuran, Hamdiye
dc.contributor.authorBayraktar, Mehmet
dc.contributor.authorOzturk, Ali
dc.contributor.authorErdogdu, Hamza
dc.date.accessioned2024-11-07T13:32:03Z
dc.date.available2024-11-07T13:32:03Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIn this study, we investigated the role and relationship between the cytokine profile and protective vitamin D by measuring their serum levels in COVID-19 intensive care unit patients with severe illnesses. A total of 74 patients were included in our study. Patients were divided into two groups. Patients in the COVID-19 group (n = 31) and individuals without a history of serious illness or infection were used as the control group (n = 43). The serum concentrations of interleukin-1 (IL-1), IL-6, IL-10, IL-21, and tumor necrosis factor-alpha (TNF-alpha) were measured by enzyme-linked immunosorbent assays. Levels of serum vitamin D were detected with Liquid chromatography-mass spectrometry methodologies. TNF-alpha, IL-1, IL-6, IL-10, IL-21, and vitamin D levels were measured in all patients. The serum cytokine levels in the COVID-19 patient group were significantly higher (151.59 +/- 56.50, 140.37 +/- 64.32, 249.02 +/- 62.84, 129.04 +/- 31.64, and 123.58 +/- 24.49, respectively) than control groups. Serum vitamin D was also significantly low (6.82 +/- 3.29) in patients in the COVID-19 group than the controls (21.96 +/- 5.39). Regarding the correlation of vitamin D with cytokine levels, it was significantly variable. Our study shows that COVID-19 patients are associated with lower serum vitamin D and higher pro-inflammatory cytokines associated with increased virus presence. Our data provide more evidence of the anti-inflammatory effect of vitamin D on COVID-19 patients and the protective effects of vitamin D on risk were demonstrated.
dc.identifier.doi10.1002/jmv.27294
dc.identifier.endpage160
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue1
dc.identifier.pmid34427934
dc.identifier.scopus2-s2.0-85113749406
dc.identifier.scopusqualityQ1
dc.identifier.startpage154
dc.identifier.urihttps://doi.org/10.1002/jmv.27294
dc.identifier.urihttps://hdl.handle.net/11480/15199
dc.identifier.volume94
dc.identifier.wosWOS:000690999300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Medical Virology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectCOVID-19
dc.subjectcytokines storm
dc.subjectpro-inflammatory cytokines
dc.subjectSARS-CoV-2
dc.subjectvitamin D
dc.titleAnalysis of serum cytokine and protective vitamin D levels in severe cases of COVID-19
dc.typeArticle

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