Phase Solubility Studies of Poorly Soluble Drug Molecules by Using O-Phosphorylated Calixarenes as Drug-Solubilizing Agents

Basit Öğe Kaydı
dc.authorid0000-0003-2904-160X
dc.contributor.authorBayrakci, Mevlut
dc.contributor.authorErtul, Seref
dc.contributor.authorYilmaz, Mustafa
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2012
dc.departmentNiğde ÖHÜ
dc.description.abstractThis study is the first report on the solubilizing effect of O-phosphorylated calix[n]arenes that form complexes with neutral molecules such as nifedipine, niclosamide, and furosemide by host-guest complexation. These complexation studies were carried out by using the phase solubility technique. From the obtained results, it was observed that the solubility of guest molecules such as nifedipine, niclosamide, and furosemide was significantly increased in the presence of host molecules tetrakis-O-(diethoxyphosphoryl)-p-tert-butylcalix[4]arene (1), tetrakis-O-(diethoxyphosphoryl)-calix[4]arene (2), bis-O-(diethoxyphosphoryl)-p-tert-butylcalix[4]arene (3), bis-O-(diethoxyphosphoryl)-calix[4]arene (4), and octakis-O-(diethoxyphosphoryl)-p-tert-butylcalix[8]arene (5). The increase in solubility of drugs by the calixarene host 1 to 5 was most probably due to inclusion complexation between drug molecules and cavities of the calixarene skeleton similar to drug-cyclodextrin complexes.
dc.description.sponsorshipS.U. Research Foundation [BAP: 10101016]; Research Laboratory of Selcuk University
dc.description.sponsorshipThe authors gratefully would like to thank S.U. Research Foundation (BAP: 10101016) for financial support.; The authors gratefully acknowledge support of this study produced from a part of the Ph.D. Thesis of Mevlut Bayrakci by the Research Laboratory of Selcuk University.
dc.identifier.doi10.1021/je200992c
dc.identifier.endpage239
dc.identifier.issn0021-9568
dc.identifier.issue1
dc.identifier.startpage233
dc.identifier.urihttps://dx.doi.org/10.1021/je200992c
dc.identifier.urihttps://hdl.handle.net/11480/4649
dc.identifier.volume57
dc.identifier.wosWOS:000298978900036
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherAMER CHEMICAL SOC
dc.relation.ispartofJOURNAL OF CHEMICAL AND ENGINEERING DATA
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titlePhase Solubility Studies of Poorly Soluble Drug Molecules by Using O-Phosphorylated Calixarenes as Drug-Solubilizing Agents
dc.typeArticle

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