Role of Propolis on Tyrosine Hydroxylase Activity and Blood Pressure in Nitric Oxide Synthase-Inhibited Hypertensive Rats

Basit Öğe Kaydı
dc.contributor.authorGogebakan, Ayse
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorSahna, Engin
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2012
dc.departmentNiğde ÖHÜ
dc.description.abstractReduction in the synthesis or bioavailability of nitric oxide plays a significant role in the development of hypertension. Propolis is a resinous product collected by honeybees from various plant sources. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines. The aim of this study was to examine the effect of propolis on blood pressure (BP), TH, and total RNA levels in the adrenal medulla, heart, and hypothalamus tissues in chronic nitric oxide synthase (NOS)-inhibited rats by N-w-nitro-L-arginine methyl ester (L-NAME). Rats received NOS inhibitor (L-NAME) for 15 days to produce hypertension and propolis for the last 5 days. TH activity and total RNA levels significantly increased in adrenal medulla, heart, and hypothalamus tissues in L-NAME-treated groups (P < .05). TH activity and total RNA levels of L-NAME+propolis-treated rats reduced (P < .05) compared with L-NAME-treated groups. TH activity in propolis-treated rats was reduced to the control values. L-NAME led to a significant increase in BP compared with the control group. Propolis administration to L-NAME-treated rats reduced BP but this was not statistically significant compared to L-NAME-treated groups. These results suggest that propolis decreases TH activity in NOS-inhibited hypertensive rats and thereby may modulate the synthesis of catecholamine and BP.
dc.description.sponsorshipNigde University [BAP 2008/25]
dc.description.sponsorshipThe Nigde University Research Fund (BAP 2008/25) is gratefully acknowledged for supporting this work. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
dc.identifier.doi10.3109/10641963.2012.665542
dc.identifier.endpage428
dc.identifier.issn1064-1963
dc.identifier.issue6
dc.identifier.pmid22471835
dc.identifier.scopus2-s2.0-84866103517
dc.identifier.scopusqualityQ3
dc.identifier.startpage424
dc.identifier.urihttps://dx.doi.org/10.3109/10641963.2012.665542
dc.identifier.urihttps://hdl.handle.net/11480/4627
dc.identifier.volume34
dc.identifier.wosWOS:000308422300007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherINFORMA HEALTHCARE
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HYPERTENSION
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjecttyrosine hydroxylase
dc.subjectL-NAME
dc.subjectnitric oxide
dc.subjectblood pressure
dc.subjectpropolis
dc.subjectrat
dc.titleRole of Propolis on Tyrosine Hydroxylase Activity and Blood Pressure in Nitric Oxide Synthase-Inhibited Hypertensive Rats
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu