Protective effect of crocin on food azo dye tartrazine-induced hepatic damage by improving biochemical parameters and oxidative stress biomarkers in rats

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dc.contributor.authorVelioglu C.
dc.contributor.authorErdemli M.E.
dc.contributor.authorGul M.
dc.contributor.authorErdemli Z.
dc.contributor.authorZayman E.
dc.contributor.authorBag H.G.
dc.contributor.authorAltinoz E.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2019
dc.departmentNiğde ÖHÜ
dc.description.abstractThe objective of the present study was to demonstrate the protective effect of crocin on the adverse effects of tartrazine on liver. Crocin is a carotenoid and a strong free radical scavenger. Forty rats were randomly divided into 4 groups (n = 10). The first group was the control group (C) and saline solution was administered to this group. The second group (Cr) was administered 50 mg/ kg crocin. The third group (T) was administered 500 mg/kg tartrazine. The fourth group (T+Cr) was administered the same doses of both crocin and tartrazine as the previous groups for 21 days. It was determined that tartrazine increased liver superoxide dismutase (SOD) activity, malondialdehyde (MDA) and total oxidant status (TOS) levels and catalase (CAT) activity, decreased glutathione (GSH), and total antioxidant status (TAS) levels. Furthermore, tartrazine administration resulted in significant increases in plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities and pathological changes in the liver. When tartrazine administered rats were treated with crocin for 21 days, the biochemical parameters improved, and liver tissues were restored. Thus, it was demonstrated that crocin had protective effects on the adverse effects caused by tartrazine administration. © 2019, Slovak Academy of Sciences. All rights reserved.
dc.description.sponsorshipAcknowledgement. The present study was sponsored by Karabuk University scientific research fund (KBU-BAP-16/2-YL-093).
dc.identifier.doi10.4149/gpb_2018039
dc.identifier.endpage82
dc.identifier.issn0231-5882
dc.identifier.pmid30657462
dc.identifier.scopus2-s2.0-85061474703
dc.identifier.scopusqualityQ3
dc.identifier.startpage73
dc.identifier.urihttps://dx.doi.org/10.4149/gpb_2018039
dc.identifier.urihttps://hdl.handle.net/11480/1569
dc.identifier.volume38
dc.identifier.wosWOS:000458604800007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherSlovak Academy of Sciences
dc.relation.ispartofGeneral Physiology and Biophysics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCrocin
dc.subjectHepatotoxicity
dc.subjectOxidative stress
dc.subjectTartrazine
dc.titleProtective effect of crocin on food azo dye tartrazine-induced hepatic damage by improving biochemical parameters and oxidative stress biomarkers in rats
dc.typeArticle

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