Screening of single nucleotide polymorphism in CD95 (APO-1/FAS) promoter region (G-1377A) in children with acute leukemia

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dc.contributor.authorAkin, Dilara F.
dc.contributor.authorOzkan, Didem T.
dc.contributor.authorKurekci, Emin
dc.contributor.authorAkar, Nejat
dc.date.accessioned2024-11-07T13:34:21Z
dc.date.available2024-11-07T13:34:21Z
dc.date.issued2018
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground CD95 is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in downregulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide polymorphism resulting in guanine-to-adenine (G>A) transition in the CD95 promoter region (position - 1377) is thought to reduce stimulatory protein 1 transcription factor binding and decrease CD95 expression. The purpose of this study is to examine a genetic polymorphism in the core promoter region of CD95 and to evaluate association between its frequency and clinical findings. Patients and methods G-1377A in the CD95 promoter region was genotyped by polymerase chain reaction and restriction endonuclease analysis finally were sequenced by Sanger Sequecing. Results Among 146 patients, CD95 G-1377A (rs2234767) single nucleotide polymorphism carriers frequencies have been identified as 25% (n=37) GA and AA 4% (n=6). This polymorphism of the distribution of the CD95 gene in children with acute leukemia will be a guide for future studies. Conclusion This polymorphism of the distribution of the CD95 gene in children with acute leukemia will be a guide for future studies. (c) 2018 The Egyptian Journal of Haematology
dc.identifier.doi10.4103/ejh.ejh_55_17
dc.identifier.endpage48
dc.identifier.issn1110-1067
dc.identifier.issn2090-9268
dc.identifier.issue2
dc.identifier.startpage45
dc.identifier.urihttps://doi.org/10.4103/ejh.ejh_55_17
dc.identifier.urihttps://hdl.handle.net/11480/15943
dc.identifier.volume43
dc.identifier.wosWOS:000441639800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofEgyptian Journal of Haematology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectacute lymphoblastic leukemia
dc.subjectacute myeloblastic leukemia
dc.subjectCD95 polymorphism
dc.titleScreening of single nucleotide polymorphism in CD95 (APO-1/FAS) promoter region (G-1377A) in children with acute leukemia
dc.typeArticle

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