Therapeutic effect of 6-shogaol on acetaminophen-induced hepatotoxicity in mice: an experimental study

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dc.contributor.authorCumaoglu, M. Oguz
dc.contributor.authorCumaoglu, B.
dc.contributor.authorTekin, Y.
dc.contributor.authorGunay, N.
dc.date.accessioned2024-11-07T13:32:35Z
dc.date.available2024-11-07T13:32:35Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractOBJECTIVE: Acetaminophen (APAP) is one of the most commonly used analgesics and antipyretics. It causes serious liver damage when taken in large quantities by adults or children. Also, 6-shogaol is an active compound obtained from ginger with anti-inflammatory and antioxidant properties. This study aimed at examining the therapeutic effect of 6-shogaol in APAP-induced hepatotoxicity. MATERIALS AND METHODS: The mice were separated into five groups. After the mice were sacrificed, the levels of alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) in the blood, glutathione (GSH) level in the liver tissue homogenate, and levels of induced nitrite oxide synthetase (INOS) and total nitrite/nitrate were measured by spectrophotometric methods. RESULTS: APAP administration significantly increased the serum levels of ALT, AST, and ALP, INOS activity in liver tissue, and total nitrite/nitrate levels compared with control and significantly decreased GSH levels. After APAP toxicity, 6-shogaol and N-acetylcysteine (NAC) administration significantly decreased the levels of ALT, AST, INOS, and total nitrite/nitrate levels and significantly increased GSH levels compared with control. Also, 6-shogaol was found to be better than NAC in increasing the GSH level. CONCLUSIONS: The study showed that 6-shogaol might have an early therapeutic effect on APAP-induced liver damage.
dc.identifier.endpage7378
dc.identifier.issn1128-3602
dc.identifier.issue20
dc.identifier.pmid36314307
dc.identifier.scopus2-s2.0-85141005542
dc.identifier.scopusqualityQ2
dc.identifier.startpage7371
dc.identifier.urihttps://hdl.handle.net/11480/15495
dc.identifier.volume26
dc.identifier.wosWOS:000904108500008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAcetaminophen
dc.subjectHepatotoxicity
dc.subjectLiver
dc.subject6-shogaol
dc.titleTherapeutic effect of 6-shogaol on acetaminophen-induced hepatotoxicity in mice: an experimental study
dc.typeArticle

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